ArticleFood science & nutrition2025
Anti-Inflammatory Effect of Goat Milk Against Acetic Acid-Induced Ulcerative Colitis in Rat Model.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Anti-Inflammatory Effect of Goat Milk Against Acetic Acid-Induced Ulcerative Colitis in Rat Model.Food science & nutrition · 2025Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The current study evaluated the protective and antioxidant effects of goat milk, alone and in combination with sulfasalazine (SAZ), against acetic acid (AA)-induced ulcerative colitis (UC) in Sprague Dawley rats. Thirty rats were divided into five groups with six rats in each group. UC was induced using 3% AA, administered intrarectally (IR) at a dose of 3 mL per rat once daily for the first three consecutive days of the experiment. Goat milk and SAZ treatments were administered orally (p.o.) for 21 days. Group I served as the normal control group and received a basal diet without UC induction. Group II was the positive control group and received 3% AA (3 mL/rat, IR) without any treatment. Group III received AA (IR) and goat milk at a dose of 40 mL/kg body weight (p.o.). Group IV received a combination of goat milk (40 mL/kg body weight, p.o.) and SAZ (250 mg/kg body weight, p.o.) following AA induction. Group V was administered AA (IR) and treated with SAZ alone at a dose of 250 mg/kg body weight (p.o.). Biochemical analysis showed that goat milk, especially in combination with SAZ, significantly reduced malondialdehyde (MDA) levels and elevated antioxidant enzyme levels including superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) (
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