Observational studyInternational journal of chronic obstructive pulmonary disease2025
Observational and Genetic Evidence Reveals the Effect of Serum Lipid Levels on COPD Risk.
Observational study in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mendelian Randomization Study in East Asian Populations Supports the Causal Relationship Between Blood Metabolites and COPD: Insights from Amino Acids, Phospholipids, Vitamin D, and Trace Elements.International journal of chronic obstructive pulmonary disease · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Disorders of lipid metabolism are linked to an increased risk of various diseases; however, their association with chronic obstructive pulmonary disease (COPD) remains unclear. This study aimed to examine the relationship between serum lipid levels and COPD risk. Methods: The methods of the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR) analyses were employed to investigate the relationships between lipids and COPD across multiple populations. Data from 2013 to 2023 were selected for the NHANES study on US population, and weighted multivariable-adjusted logistic regression was employed as the primary statistical method. And data utilized for the MR analysis were derived from genome-wide association studies (GWAS) conducted on European and East Asian populations, with inverse-variance weighted (IVW) method serving as the principal statistical approach. Results: The NHANES analyses indicated that higher levels of total cholesterol (TC) (OR = 0.85, 95% CI = 0.77-0.93), non-high-density lipoprotein cholesterol (non-HDL-C) (OR = 0.86, 95% CI = 0.78-0.94) and low-density lipoprotein cholesterol (LDL-C) (OR = 0.85, 95% CI = 0.74-0.97) were associated with a reduced risk of COPD in the US population. In the MR analyses, TC (OR = 0.90, 95% CI = 0.84-0.95), non-HDL-C (OR = 0.91, 95% CI = 0.85-0.96), and LDL-C (OR = 0.88, 95% CI = 0.82-0.94) were causally linked to a decreased risk of COPD in the European population. Similar associations were observed in the East Asian population. Conclusion: Our study identified associations between TC, non-HDL-C, and LDL-C with a reduced risk of COPD. This underscores the importance of monitoring lipid metabolism in patients with COPD and provides supporting evidence for the use of lipid-based therapies in its treatment.
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