Evidence map›Paper›PMID 40786706›Full record

ArticleAPL bioengineering2025

Single-cell RNA and bulk sequencing analysis reveals that formononetin inhibits GTSF1 to exert anti-osteosarcoma effects.

Tianyu Xie, Jiming Liang, Chengsen Lin, Wenyu Feng, Mingxiu Yang, Shanhang Li, Liang Xiong, Kai Luo, Feicui Li, Shengping Tang and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Tianyu XieDepartment of Traumatic Orthopaedic, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Jiming LiangDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Chengsen LinDepartment of Emergency, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Wenyu FengDepartment of Orthopaedic, The Second Affiliated Hospital of Guangxi Medical University, 530005 Nanning, China.
Mingxiu YangDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Shanhang LiDepartment of Bone and Soft Tissue, Affiliated Tumour Hospital of Guangxi Medical University, 530021 Nanning, China.
Liang XiongDepartment of Traumatic Orthopaedic, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Kai LuoDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Feicui LiDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Shengping TangDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Shangyu LiuDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.ORCID https://orcid.org/0009-0009-4453-784X
Qian HuangDepartment of Traumatic Orthopaedic, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.ORCID https://orcid.org/0000-0002-0932-5181
Shijie LiaoDepartment of Traumatic Orthopaedic, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Jianhong LiuDepartment of Traumatic Orthopaedic, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.ORCID https://orcid.org/0009-0007-2010-6901
Yangjie CaiDepartment of Traumatic Orthopaedic, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Fuxing TangDepartment of minimally invasive spinal surgery, Yulin Orthopedics Hospital of Chinese and Western Medicine, 53700 Yulin, Guangxi, China.
Haijun TangDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.
Qingjun WeiDepartment of Orthopaedic, The Second Affiliated Hospital of Guangxi Medical University, 530005 Nanning, China.
Yunhua LinDepartment of Traumatic Orthopaedic, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.ORCID https://orcid.org/0000-0003-3216-3456
Yun LiuDepartment of Spine and Orthopedic Surgery, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, China.ORCID https://orcid.org/0000-0002-7745-1083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As the most common primary malignant bone tumor, osteosarcoma (OS) is characterized by drug resistance and poor prognosis, highlighting the urgent need for promising therapeutic agents. Formononetin (FMN), a natural product derived from

Identifiers

PMID40786706
PMCPMC12335348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.