ArticleChemistry methods : new approaches to solving problems in chemistry2021
Advancement in Organic Synthesis through High Throughput Experimentation.
Article in Chemistry methods : new approaches to solving problems in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- An autonomous lab for data-driven homogeneous catalysis.Nature communications · 2026Article
- Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?Journal of medicinal chemistry · 2025Review
- Advancing Organic Chemistry Using High-Throughput Experimentation.Angewandte Chemie (International ed. in English) · 2025Review
- Computational tools for the prediction of site- and regioselectivity of organic reactions.Chemical science · 2025Review
- Factors to Consider for Synthesis in 1536-Well Plates─An Amide Coupling Case Study for PROTAC Synthesis.The Journal of organic chemistry · 2025Article
- Unveiling New Reactivities in Complex Mixtures: Synthesis of Tricyclic Pyridinium Derivatives.Journal of the American Chemical Society · 2025Article
- Adaptive experimentation and optimization in organic chemistry.Beilstein journal of organic chemistry · 2025Article
- An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.Angewandte Chemie (International ed. in English) · 2024Article
- Integrated System Built for Small-Molecule Semiconductors via High-Throughput Approaches.Journal of the American Chemical Society · 2023Article
- MOFganic Chemistry: Challenges and Opportunities for Metal-Organic Frameworks in Synthetic Organic Chemistry.Chemistry of materials : a publication of the American Chemical Society · 2023Article
- Continuous Flow Synthesis of A2E Guided by Design of Experiments and High-Throughput Studies.ACS bio & med chem Au · 2022Article
- A General, Multimetallic Cross-Ullmann Biheteroaryl Synthesis from Heteroaryl Halides and Heteroaryl Triflates.Journal of the American Chemical Society · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Exploration of synthetic transformations using high throughput experimentation (HTE) can accelerate the rapid discovery of optimal conditions for organic reactions and improve our understanding of those processes and synthetic route for different applications. The surge in high throughput techniques has been applied to a broad range of methods and target-oriented reaction optimizations across a diverse array of bond-constructions. In this Minireview, we describe HTE based workflows, discuss different transformations that have been evaluated using HTE platforms with a focus on homogeneous catalytic reactions, and highlight challenges reported in the field since 2016. The HTE efforts are grouped by the type of bonds being formed, for instance, carbon-carbon (C-C), carbon-nitrogen (C-N), carbon-halogen or carbon-oxygen (C-X) bonds, as well as photochemical transformations and hydrogenations. The potential of HTE to rapidly guide the optimization of multiple synthetic challenges makes it a very attractive and powerful tool for synthetic organic chemists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.