ArticleMaterials today. Bio2025
Chiral gold nanoparticles manipulate osteoimmune microenvironment via macrophage autophagy for bone regeneration.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Chirality and morphology-dependent siRNA delivery for targeted lung cancer therapy with intrinsically chiral gold nanoparticles.Materials today. Bio · 2026Article
- Recent advances in immunoregulatory biomaterials for tendon healing: From immune remodeling to functional regeneration.Materials today. Bio · 2026Review
- [Bioactive substances delivery for bone repair via nanocomposites: advantages, mechanisms, and emerging trends].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune microenvironment orchestrates bone regeneration, which can be manipulated by macrophage autophagy. Herein, gold nanoparticles with L/D (left-handed or right-handed)-chirality (L/D-AuNPs) were synthesized with chiral glutathione ligands to stereoselectively regulate macrophage autophagy, and further manipulate immune microenvironment for bone regeneration. Notably, L-AuNPs exhibited superior macrophage uptake efficiency and higher autophagy level compared to D-AuNPs. Meanwhile, L-AuNPs improved the osteogenic microenvironment, further promoting bone regeneration. In addition, the
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