Evidence map›Paper›PMID 40786650›Full record

ArticleBrain, behavior, & immunity - health2025

The impact of acute COVID-19 symptoms on insomnia: A longitudinal study among medical students.

Yue Zhu, Xiaoyang Qin, Yuhong Lu, Yuenan Yu, Rongxun Liu, Rongxin Zhu, Kuan-Pin Su, Fei Wang

Abstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yue ZhuEarly Intervention Unit, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Xiaoyang QinEarly Intervention Unit, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Yuhong LuEarly Intervention Unit, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Yuenan YuEarly Intervention Unit, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Rongxun LiuSchool of Psychology of Xinxiang Medical University, Xinxiang, China.
Rongxin ZhuEarly Intervention Unit, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Kuan-Pin SuMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
Fei WangEarly Intervention Unit, Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The COVID-19 pandemic has profoundly disrupted global mental health. Medical students, already vulnerable to high stress, experience heightened psychological distress. This study aimed to investigate the association between acute COVID-19 infection and the development of psychological symptoms in medical students, exploring the role of specific COVID-19 symptoms and lifestyle factors. Methods: A longitudinal study of 2359 medical students assessed psychological symptoms (depression, anxiety, insomnia) before and after COVID-19 infection. Logistic regression models, adjusted for confounders, examined the relationship between COVID-19 status (with or without infection), and the onset of psychological symptoms. The study also explored acute COVID-19 symptoms and lifestyle factors associated with psychological symptoms in the COVID-19 infected (COVID+) group. Findings: The COVID + group exhibited significantly greater increases in depression and insomnia compared to non-infected group. COVID-19 infection was significantly associated with the onset of insomnia post-infection (OR [95 % CI] 1.83 [1.05-3.21]). Moderate to severe acute symptoms, including sleep disturbances (2.20 [1.17-4.14]), decreased attention/memory (2.47 [1.02-6.00]), and breathlessness (2.05 [1.08-3.85]), were identified as risk factors for onset of insomnia. Regular exercise was found to be negatively associated with the onset of insomnia (0.54 [0.33-0.88]). Conclusion: Early intervention targeting these acute-phase risk symptoms is crucial for preventing long-term insomnia. Regular exercise is effective in preventing the development of insomnia in medical students following COVID-19 infection. These findings will assist in formulating targeted interventions to address recurrent infections in the post-pandemic era.

Indexed as

Acute COVID-19 symptomsInsomniaLong-COVID

Identifiers

PMID40786650
PMCPMC12332912

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.