Evidence map›Paper›PMID 40786618›Full record

ArticleAdvanced materials technologies2025

Photonic Crystal Enhanced Microscopy on a 2D Photonic Crystal Surface.

Weinan Liu, Siyan Li, Edmond Chow, Seemesh Bhaskar, Ying Fang, Brian T Cunningham

Abstract read
In one paragraph

Article in Advanced materials technologies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weinan LiuDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 306 N Wright St MC 702, Urbana, IL 61801, USA.
Siyan LiDepartment of Pathobiology, University of Illinois at Urbana-Champaign, 2001 S Lincoln Ave, Urbana, IL 61802, USA.
Edmond ChowHolonyak Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, 208 N Wright St, Urbana, IL 61801, USA.
Seemesh BhaskarDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 306 N Wright St MC 702, Urbana, IL 61801, USA.
Ying FangDepartment of Pathobiology, University of Illinois at Urbana-Champaign, 2001 S Lincoln Ave, Urbana, IL 61802.
Brian T CunninghamDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 306 N Wright St MC 702, Urbana, IL 61801, USA.

Funding

Exosome separation and digital resolution detection of blood-based nucleic acid biomarkers for noninvasive therapeutic diagnostics in cancerR01EB029805 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CUNNINGHAM, BRIAN T., DEMIRCI, UTKAN · 2020 to 2023
$2.1M
NIBIB NIH HHS R01 EB029805
6 · The paper itself

Abstract

Digital-resolution biosensing based on resonant reflection from photonic crystals (PC) has demonstrated significant potential for detection of proteomic and genomic biomarkers in serology, infectious disease diagnostics, and cancer diagnostics. An important intrinsic characteristic of resonant metamaterial surfaces is that enhanced electromagnetic fields are not uniformly distributed, resulting in spatially variable light-matter interactions with nanoparticle tags that signal the presence of biomarker molecules. In this work, we compare the spatial uniformity of resonantly enhanced, surface-confined electromagnetic fields of a one-dimensional (1D) PC with a two-dimensional (2D) PC with fourfold symmetry. When illuminated with unpolarized light, the simultaneously excited electromagnetic fields of transverse electric and transverse magnetic modes of the 2D PC present equally strong but complementary spatial distribution, leading to a > 100% increased average near-field intensity accompanied with a > 50% compressed standard deviation compared to the 1D PC. Utilizing Photonic Resonator Absorption Microscopy (PRAM) to experimentally measure the absorption uniformity of ~80 nm gold nanoparticles distributed upon the PC surface, we observe a > 100% improvement of the signal uniformity when using the 2D PC. Overall, we demonstrate improvement in AuNP detection contrast, uniformity, and point spread function by PRAM performed upon a 2D PC surface.

Indexed as

Digital Resolution BiosensorsNear-fieldPhotonic CrystalsSurface Plasmons

Identifiers

PMID40786618
PMCPMC12333900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.