ArticleCaspian journal of internal medicine2025
Comparing the results of knee osteoarthritis treatment with intra-articular injection of steroid (methylprednisolone) and hyaluronic acid.
Article in Caspian journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Treatments for osteoarthritis, including steroids and nonsteroidal anti-inflammatory drugs, are not very satisfactory. Therefore, we decided to compare the therapeutic results of intra-articular injection of hyaluronic acid and methylprednisolone. Methods: In this single-blind clinical trial, 132 patients with osteoarthritis of the knee were randomly assigned to two treatment groups; hyaluronic acid and methylprednisolone. Treatment results were measured based on the standard McMaster Universities Arthritis Index (WOMAC) questionnaire. Results: Although the desired level of satisfaction was higher in the short-term in the methylprednisolone group and in the long-term in the hyaluronic acid group, however, these differences were not significant. Conclusion: The recovery of patients is better with methylprednisolone injection in the short term and hyaluronic acid in the long term. However, since methylprednisolone has complications, it is recommended to consider hyaluronic acid as a suitable drug in the treatment process.
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