ArticleCureus2025
Beyond the Rash: The Devastating Course of Meningococcal Purpura Fulminans in an Unvaccinated Young Adult.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpura fulminans (PF) is a life-threatening thrombotic disorder characterized by rapidly progressive cutaneous hemorrhagic necrosis, disseminated intravascular coagulation (DIC), and multi-organ failure. Most commonly associated with meningococcemia, PF requires early recognition for optimal outcomes. This report presents the case of a 26-year-old immunocompetent but unvaccinated male who developed PF secondary to meningococcemia, complicated by refractory septic shock, multi-organ failure, and extensive tissue necrosis. His clinical course underscores the aggressive nature of this condition, the critical need for early recognition, and the importance of primary prevention through meningococcal vaccination. The patient's unvaccinated status highlights persistent gaps in vaccination uptake, particularly among individuals outside of university settings. Co-infection with COVID-19 and underlying alcohol use disorder may have contributed to immune dysregulation and increased disease severity. This case also raises awareness of the potential role of COVID-19 in the pathogenesis of meningococcemia. PF remains a dermatologic and hematologic emergency with high mortality, necessitating rapid diagnosis and a multidisciplinary treatment approach. Strengthening vaccination education and advocacy is essential to reduce the burden of PF and its complications.
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