Evidence map›Paper›PMID 40786250›Full record

ArticleDrug design, development and therapy2025

Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro.

Mengjiao Ma, Hua Fan, Yidan Dong, Tianyi Feng, Longping Peng, Maolin Zhou, Feifei Liu, RueyJyh Lee, Rongxue Wu, Qiong Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengjiao Ma *Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.ORCID 0009-0003-3299-0272
Hua Fan *Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Yidan DongDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Tianyi FengDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Longping PengDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Maolin ZhouDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Feifei LiuDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
RueyJyh LeeDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Rongxue WuDepartment of Medicine/Cardiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
Qiong WuDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Youhua WangDepartment of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Combined with RNA sequencing and experimental verification methods to investigate KXD's potential role and underlying mechanisms in cTnT Methods: UPLC-Q-TOF-MS analysis was employed to identify the absorbed constituents from KXD in mice blood. cTnT Results: 11 compounds from KXD were identified in the blood. KXD improved cardiac dysfunction and alleviated interstitial fibrosis and cardiomyocyte hypertrophy in cTnT Conclusion: KXD attenuated left ventricular remodeling and cardiomyocyte apoptosis in cTnT

Indexed as

ApoptosisConnexin 43Drugs, Chinese HerbalMyocytes, CardiacVentricular RemodelingAnimalsCells, CulturedDose-Response Relationship, DrugMaleMAP Kinase Kinase Kinase 5MiceMice, Inbred C57BLMice, TransgenicRatsSignal TransductionConnexin 43Drugs, Chinese HerbalGJA1 protein, mouseMap3k5 protein, mouseMAP Kinase Kinase Kinase 5ASK1/JNK signaling pathwaycardiomyocyte apoptosisdilated cardiomyopathygap junctionsKuoxin Decoction

Identifiers

PMID40786250
PMCPMC12333879

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.