Evidence map›Paper›PMID 40786127›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2025

Assessment of Patient-Reported Outcome Measures in Patients Undergoing Bowel Preparation With Mannitol for Colonoscopy: The SATISFACTION Study.

Gian Eugenio Tontini, Cristiano Spada, Peter Uebel, Renato Cannizzaro, Giorgio Ciprandi, Maurizio Vecchi

Registry-linked trialAbstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04759885 (Efficacy and Safety of mAnniTol in Bowel Preparation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04759885 phase2 / phase3completednot on this map

Efficacy and Safety of mAnniTol in Bowel Preparation: Assessment of Adequacy and Presence of Intestinal levelS of Hydrogen and Methane During Elective Colonoscopy aFter mAnnitol or Standard Split 2-liter Polyethylene Glycol Solution Plus asCorbaTe - a Phase II/III, International, Multicentre, Randomized, Parallel-group, endoscOpist-bliNded, Dose-finding/Non-inferiority Study - SATISFACTION

TypeinterventionalSponsorNTC srlRan2020 to 2021Enrolled886ConditionsElective ColonoscopyArmsPhase II: NTC015 low dose, Phase II: NTC015 medium dose, Phase II: NTC015 high dose, Phase III: NTC015 selected dose, Phase III: Polyethylene glycol plus ascorbate solution (2L PEG ASC)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gian Eugenio TontiniDepartment of Pathophysiology and Organ Transplantation University of Milan Milan Italy.
Cristiano SpadaDigestive Endoscopy Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy.
Peter UebelPraxis für Gastroenterologie Und Fachärztliche Innere Medizin Im Haus der Gesundheit Ludwigshafen Germany.
Renato CannizzaroOncological Gastroenterology Centro di Riferimento Oncologico di Aviano (CRO), National Cancer Institute, IRCCS Aviano Italy.
Giorgio CiprandiOutpatient Department Casa di Cura Villa Montallegro Genoa Italy.ORCID https://orcid.org/0000-0001-7016-8421
Maurizio VecchiDepartment of Pathophysiology and Organ Transplantation University of Milan Milan Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bowel preparation for colonoscopy causes significant discomfort to patients. Large volumes, unpleasant taste, and split-dosing are the main disadvantages of most laxatives. Oral mannitol could be an attractive option because it acts quickly, requires low volumes, and has a pleasant taste. Aims: A Phase III study (SATISFACTION) compared oral mannitol with polyethylene glycol-ascorbate (PEG-ADC). This Methods: The SATISFACTION Phase III study was an international, multicenter, randomized (1:1), parallel-group, endoscopist-blinded, non-inferiority trial. Taste of preparations, ease of use, and willingness to repeat the preparation with the same product were scored and assessed by the patients. Results: Bowel preparation with oral mannitol resulted in a better patient satisfaction profile for all PROMs evaluated. Conclusion: Oral mannitol for bowel preparation achieved high patient satisfaction and might be a valuable option for colonoscopy. Trial Registration: ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885).

Indexed as

bowel preparationcolonoscopyoral mannitolpatient‐reported outcomes

Identifiers

PMID40786127
PMCPMC12332180

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