ArticleEFSA journal. European Food Safety Authority2025
Statement on the use and interpretation of the margin of exposure approach.
Article in EFSA journal. European Food Safety Authority, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- Overview of Current Regulatory and Methodological Approaches for the Risk Assessment of Mycotoxins.Toxins · 2026Review
- Update of the risk assessment on emerging and novel brominated flame retardants in food.EFSA journal. European Food Safety Authority · 2026Article
- Lipid Metabolic Effects Induced by Individual and Combined Exposure to Multiple Food Additives in Human Cells.Toxics · 2026Article
- Relevance and challenges of exposome studies for environmental health research.Environmental health : a global access science source · 2026Review
- Occurrence, Dietary Exposure Scenarios and Risk Assessment of Aflatoxins from Dried Fruits and Chocolates in Armenia.Foods (Basel, Switzerland) · 2026Article
- Flavouring Group Evaluation 82 Revision 2 (FGE.82Rev2): Consideration of epoxides evaluated by JECFA.EFSA journal. European Food Safety Authority · 2026Article
- Article
- Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026Review
- Application of in vitro to in vivo extrapolation (IVIVE) to inform chemical health guidance value derivation-sample case studies comparing neuro-, hepato-, and developmental toxicities.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- A Heatmap-Based Risk-Benefit Assessment of Traditional and Processed Meat Products.Foods (Basel, Switzerland) · 2026Review
- Peer review of the pesticide risk assessment of the active substance ziram.EFSA journal. European Food Safety Authority · 2026Article
- Risk Assessment of Chemical Mixtures in Foods: A Comprehensive Methodological and Regulatory Review.Foods (Basel, Switzerland) · 2026Review
- Advances in the neurotoxicity of ecological pesticide maneb: mechanisms and implications for human health.Frontiers in public health · 2026Review
- Guidance document on the submission of data for the evaluation of the safety and efficacy of substances for the removal of microbial surface contamination of foods of animal origin intended for human consumption.EFSA journal. European Food Safety Authority · 2026Article
- Guidance on the scientific data requirements for an application for authorisation of a food additive submitted under Regulation (EC) No 1331/2008.EFSA journal. European Food Safety Authority · 2026Article
- Review
- Probabilistic health risk assessment for dietary exposure to 3-monochloropropane-1,2-diol (3-MCPD) and 1,3-dichloropropan-2-ol (1,3-DCP) through consumption of commercial soup.Scientific reports · 2025Article
- Health Risk Assessment of Dietary Chemical Exposures: A Comprehensive Review.Foods (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The margin of exposure (MOE) is a risk assessment tool used to evaluate the safety of substances in food and feed. Adopted by the European Food Safety Authority (EFSA) in 2005, the MOE is calculated as the ratio between a Reference Point (RP) and the estimated exposure. While some regulatory bodies use 'margin of safety' (MOS) interchangeably with MOE, others define it differently, leading to inconsistencies in interpretation. To address this, EFSA has standardised its terminology, establishing MOE as a primary metric for safety assessments across human and animal health evaluations. In addition, the meaning and interpretation of terms used to qualify a 'concern' is elaborated. The EFSA definitions will come into force from when this statement is published. By refining these definitions and ensuring consistent terminology across sectors, EFSA aims to improve clarity and transparency in its risk assessments, facilitating effective communication.
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