ArticleFrontiers in medicine2025
The effect of ultrasound-guided thoracic paravertebral nerve block combined with hydromorphone on postoperative analgesia and inflammatory response in thoracoscopic surgery: a randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The perioperative effect of ERAS protocol in patients with lung cancer: a randomized controlled study.Journal of cardiothoracic surgery · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aims to explore the effects of a multimodal postoperative analgesia regimen of ultrasound-guided thoracic paravertebral block (UTPB) combined with hydromorphone patient-controlled intravenous analgesia (PCIA) on postoperative analgesia, early recovery, and traumatic inflammatory response in patients undergoing thoracoscopy surgery, providing a basis for clinical application. Methods: In this single-blind, randomized controlled trial (RCT), we enrolled 64 patients scheduled for thoracoscopic lobectomy of the lung. The patients were randomly assigned into two groups of UTPB combined with hydromorphone PCIA group (T group) and hydromorphone PCIA group (H group) according to the random number table method. T group underwent UTPB with ropivacaine before induction of general anesthesia. H group is the control group. Both groups underwent PCIA after surgery, with the analgesic formula being 50 μg/kg of hydromorphone. The analgesic solution is prepared with 100 mL of sodium chloride injection, a background dose of 2.0 mL/h, a patient-controlled analgesia dose of 2 mL, and a locking time of 30 min. Results: Compared with H group, T group showed a significant decrease in visual analog scale (VAS) scores and an increase in bruggrmann comfort scale (BCS) scores within 8 h after surgery, and a decrease in opioid analgesic doses during and within 8 h after surgery. The levels of serum C-reactive protein (CRP), Interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) in T group were lower than those in H group at 24 h after surgery. The first time patients in T group got out of bed after surgery was earlier than that in H group. Two groups of patients had no serious adverse reactions. Conclusion: Ultrasound-guided thoracic paravertebral block combined with hydromorphone PCIA can achieve good analgesic effects in thoracoscopic lobectomy surgery. It can reduce the amount of opioid drugs used during the perioperative period, alleviate the body's inflammatory response, and promote rapid recovery of patients. It has clinical application value. Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=201650, identifier ChiCTR2300074082.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.