Evidence map›Paper›PMID 40786016›Full record

ArticleACG case reports journal2024

Intrahepatic Cholangiocarcinoma With Sarcomatous Transformation: Demonstrating the Transition Zone.

Tomonari Shimoda, Kazuhiro Takahashi, Kei Asayama, Ryota Matsuoka, Tatsuya Oda

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACG case reports journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tomonari ShimodaCenter for Medical Education and Training, University of Tsukuba Hospital, Tsukuba, Japan.ORCID https://orcid.org/0000-0001-5092-3127
Kazuhiro TakahashiDepartment of Gastrointestinal and Hepatobiliary Pancreatic Surgery, University of Tsukuba, Tsukuba, Japan.
Kei AsayamaDepartment of Diagnostic Pathology, University of Tsukuba, Tsukuba, Japan.
Ryota MatsuokaDepartment of Diagnostic Pathology, University of Tsukuba, Tsukuba, Japan.
Tatsuya OdaDepartment of Gastrointestinal and Hepatobiliary Pancreatic Surgery, University of Tsukuba, Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrahepatic cholangiocarcinoma with sarcomatous transformation (ICC-S) is a rare, aggressive neoplasm with epithelial and sarcomatous elements. We report a rapid progression of ICC-S in a 66-year-old woman. Initially, a seemingly benign 8-cm mass was observed. However, the tumor doubled to 16 cm within 3 months during follow-up. Partial hepatectomy confirmed ICC-S and histopathological examination showed cytokeratin 7 and vimentin positivity in epithelial and sarcomatous components, respectively. An analysis of transition zone indicated epithelial-mesenchymal transition as a mechanism for sarcomatous transformation. We provide the first detailed immunohistochemical analysis of the transition zone in ICC-S, highlighting epithelial-mesenchymal transition's role in pathogenesis.

Indexed as

cholangiocarcinomaliversarcomatous transformation

Identifiers

PMID40786016
PMCPMC12334209

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.