ArticleVirology & immunology journal2024
The Role of NEU1 in Coronavirus Infection and Pathogenesis.
Article in Virology & immunology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) pandemic, resulting in millions of infections and deaths worldwide. Although vaccines are available, they appear to be less efficacious against newly emerging variants of the virus. Thus, therapeutic modalities are urgently needed. The coronavirus genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein, and envelope (E) protein, all of which are required to produce a structurally complete viral particle. N protein is one of the most abundant structural proteins, participates in the regulation of viral replication and virion assembly, and is a major immunogen in coronavirus infection-induced disease. Sialylation is the addition of sialic acids to the terminal glycans of glycoproteins and glycolipids, which act as key components for biological functions of glycoproteins or glycolipids. Sialidases (or neuraminidases) are glycosidases that remove sialic acid residues (desialylation) from glycan portions of glycoproteins or glycolipids. Through desialylation, sialidases modulate the functionality of sialic acid-containing molecules and are involved in both physiological and pathological pathways. This review aims to explore the current understanding of NEU1's involvement in coronavirus infection and pathogenesis, synthesizing available research and identifying areas for future investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.