ArticleQuantitative imaging in medicine and surgery2025
Potential predictive value of myocardial strain and strain rate for late gadolinium enhancement in children with a history of Kawasaki disease.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disease-Phase Myocardial Dysfunction by Strain Imaging in Kawasaki Disease: A Systematic Review and Meta-Analysis.Echocardiography (Mount Kisco, N.Y.) · 2026Pooled it
- Multimodal Echocardiographic Assessment in Intravenous Immunoglobulin-Resistant Kawasaki Disease: From Prediction to Long-Term Surveillance.Echocardiography (Mount Kisco, N.Y.) · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Kawasaki disease (KD) is an acute pediatric vasculitis with significant implications for coronary arteries and myocardium, potentially leading to long-term myocardial fibrosis. With the advancements in speckle tracking echocardiography (STE), ultrasound parameters have been shown to be reliable in the early detection of structural and functional myocardial abnormalities, thus mitigating some limitations of cardiac magnetic resonance imaging (MRI). Despite its gold standard status for assessing myocardial fibrosis, the application of cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) in pediatrics is restricted. Therefore, this study aimed to investigate the correlation between myocardial strain parameters and LGE in children with KD. Methods: We prospectively recruited 100 children with KD and 25 healthy control (HC) children. Left ventricular (LV) function and LGE in the children were evaluated concurrently using echocardiography and CMR. Results: Of the 55 KD children (11 LGE-positive, 44 LGE-negative) and 22 HCs, LGE positivity was higher among those with giant coronary aneurysms (GCAs) and medium coronary aneurysms (MCAs). LGE-positive patients exhibited significantly reduced LV global longitudinal strain (GLS) and strain rates, including 4-chamber GLS [mid-myocardial layer (Mid): 16.82%±5.50% Conclusions: In the chronic phase, patients with KD may be at risk of myocardial fibrosis, underscoring the importance of evaluating myocardial function and LGE. Our study indicates that STE could be a valuable tool for assessing focal fibrosis in children with chronic-phase KD. However, due to limitations such as a small sample size, high dropout rate of CMR, and differences in LGE distribution, future studies with larger sample sizes are needed to validate these findings and their predictive efficacy.
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