ArticleQuantitative imaging in medicine and surgery2025
Inflammatory reaction in the acute phase of Kawasaki disease may better predict chronic cardiac dysfunction than coronary artery lesions.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Kawasaki disease (KD) is a pediatric acute vasculitis affecting the coronary arteries and cardiac tissues. Research has been conducted on the assessment of acute cardiac function in KD; however, chronic cardiac dysfunction remains understudied, particularly in terms of coronary artery lesion (CAL) grading and acute-phase inflammatory markers. This study aimed to assess the effect of CAL grading on chronic cardiac function in KD patients, and explore the association between CAL grading and acute-phase inflammatory markers. Methods: A prospective study was conducted on 25 children with giant coronary aneurysms (GCAs) and gender-, height-, and weight-matched subgroups. Chronic cardiac function and inflammatory markers were assessed using echocardiography and laboratory tests. Results: The KD group showed significantly impaired left ventricular function compared to the healthy control group, including reduced global longitudinal strain (19.94%±3.42% Conclusions: Chronic cardiac dysfunction in KD patients is affected by CAL grading and acute-phase inflammatory markers. Integrating inflammatory indicators into CAL risk stratification could enhance clinical management strategies. Further research with larger cohorts needs to be conducted to validate these findings and establish longitudinal monitoring protocols.
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