ArticleQuantitative imaging in medicine and surgery2025
Diffusion tensor image analysis along the perivascular space index and visual analogue scales in female patients with patent foramen ovale and migraine perform better after percutaneous closure.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The emerging role of the meningeal lymphatic and glymphatic systems in migraine pathophysiology: a systematic review.The journal of headache and pain · 2026Pooled it
- Reduced choroid plexus volume aggravates the glymphatic system burden in patients with patent foramen ovale-related migraine with aura.Neuroradiology · 2026Article
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8 authors.
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Abstract
Background: Patent foramen ovale (PFO) is more common in females and often complicates with migraine; however, its mechanism is not completely definite. This study aimed to explore whether a decline of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index exists which partially indicates glymphatic function, examine the relationship between diffusivity parameters, DTI-ALPS index, and visual analogue scales (VAS), and further investigate how the DTI-ALPS index and VAS perform after percutaneous closure in patients with PFO and migraine. Methods: Female patients with PFO and migraine without aura were prospectively included; they underwent diffusion tensor imaging (DTI) scanning and received VAS scores before and after percutaneous closure. Healthy controls (HC) without migraine were recruited from the community and underwent DTI scanning. Diffusivity parameters in the x-axis, y-axis, and z-axis from association and projection fibers (D Results: A total of 60 female participants were included. Among them, 20 patients with PFO and migraine had a significantly lower DTI-ALPS index in comparison with HC on the left hemisphere (P=0.005) and right hemisphere (P=0.034) as well as average DTI-ALPS index (P=0.003). The areas under the receiver operating characteristic curve (ROC; AUCs) of the DTI-ALPS index were 0.70 on the left hemisphere and 0.66 on the right, and the average DTI-ALPS index covered the largest AUC of 0.73 using a cut-off value of 1.54 with a sensitivity of 0.85 and a specificity of 0.55. Higher D Conclusions: Patients with PFO and migraine exhibited a decline of the DTI-ALPS index, which possibly reveals a trend of decreased interstitial fluid (ISF) metabolism and partly indicates glymphatic system dysfunction. Besides, the DTI-ALPS index and VAS improved after percutaneous closure, which might imply an improvement of the glymphatic system and a relief of migraine, which further highlighte the value of the closure surgery. Further, the increase of D
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