ArticleQuantitative imaging in medicine and surgery2025
Evaluation of pulmonary perfusion and ventilation in suspected chronic thromboembolic pulmonary hypertension via phase-resolved functional lung magnetic resonance imaging: correlations with hemodynamics and cardiopulmonary function.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Performance of Magnetic Resonance Imaging in Chronic Thromboembolic Pulmonary Hypertension: A Systematic Review.Journal of medical imaging and radiation oncology · 2026Pooled it
- Feasibility of quantitative pulmonary function imaging in real-world cardiovascular magnetic resonance.The international journal of cardiovascular imaging · 2026Article
- Phase-resolved functional lung magnetic resonance imaging for evaluation of lung perfusion and ventilation in fibrosing interstitial lung diseases.Insights into imaging · 2026Article
- Small vessel disease in chronic thromboembolic pulmonary hypertension: a comprehensive narrative review of multimodality imaging evaluation.Cardiovascular diagnosis and therapy · 2026Review
- External validation of a commercial AI system for pulmonary embolism detection on chest CTPA: a multicenter study.Frontiers in molecular biosciences · 2026Article
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Abstract
Background: Phase-resolved functional lung (PREFUL) magnetic resonance imaging (MRI) is a reliable, noninvasive method for assessing pulmonary ventilation and perfusion. However, the differences in subgroups of patients with chronic pulmonary embolism (CPE) have not been thoroughly investigated, and there may be significant clinical value in examining noninvasive methods for evaluating hemodynamics and right heart function in patients with CPE. This study aimed to evaluate pulmonary perfusion and ventilation in patients with suspected chronic thromboembolic pulmonary hypertension (CTEPH) via PREFUL MRI and further determined the correlations of these findings with right heart catheterization (RHC), right heart function indicators, and pulmonary function test results. Methods: A retrospective analysis was performed on patients with suspected CTEPH who were referred to our center between June 2020 and September 2022. All patients underwent RHC or echocardiography, pulmonary angiography (PA), ventilation-perfusion (V/Q) lung scan, or CTPA, with PREFUL MRI being conducted within 2 weeks of these tests. The diagnoses of CTEPH and chronic thromboembolic pulmonary disease (CTED) were established through multidisciplinary team discussions. Mean parameter values from five PREFUL MRI slices were calculated, including normalized perfusion (Q Results: In total, 42 patients (26 men and 16 women; mean age 53.5±13.5 years) with suspected CTEPH were analyzed: 31 had CTEPH and 11 had CTED. Significant differences between the two groups were found in Q Conclusions: Quantitative parameters obtained from PREFUL MRI were correlated with hemodynamic status and cardiopulmonary function in patients with CTEPH or CTED. PREFUL MRI perfusion parameters demonstrated strong diagnostic performance for CTEPH, indicating their clinical potential.
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