ArticleQuantitative imaging in medicine and surgery2025
Improved methodology for establishing a mitral regurgitation animal model guided by intracardiac echocardiography.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mitral regurgitation (MR) is the most common valvular heart disease in the general population. Establishing a reproducible and stable MR model is crucial for exploring the pathogenesis and treatment strategies of MR. This study optimized the entire modeling process based on the transcatheter method, aiming to provide a more reliable and stable strategy for constructing large animal models of MR. Methods: A total of 12 adult male Small-tailed Han sheep were randomly allocated using a random number table into 2 groups (n=6 each): an intracardiac echocardiography (ICE) group and a transthoracic echocardiography (TTE) group. MR models were established in both groups by severing mitral valve chordae tendineae using biopsy forceps under ICE and TTE guidance, respectively. Successful model establishment was defined as an intraoperative regurgitation area ≥4 cm Results: One sheep in the ICE group succumbed to heart failure on the 65th day post-operation, whereas the remaining 11 sheep survived until the end of the observation period. Postoperative ultrasound follow-up at 7, 60, and 90 days revealed significantly larger regurgitant jet areas in the ICE group (7.7±3.1, 8.8±5.5, 6.9±2.7 cm Conclusions: The ICE-guided method for establishing an MR model is simple, minimally invasive, highly reproducible, and capable of producing significant and stable regurgitation. This model is applicable for preclinical evaluation of interventional devices and research on pathophysiology.
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