ArticleQuantitative imaging in medicine and surgery2025
Genetic insights into the mediating role of cardiac function in hypertension-induced brain cortical changes: a Mendelian randomization study with cardiac magnetic resonance imaging.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypertension adversely affects both cardiac and cerebral structure and function. However, the underlying mechanisms mediating hypertension-induced brain remodeling remain unclear, particularly the role of cardiac dysfunction in this process. This study aimed to assess the causal association between hypertension and alterations to the cerebral cortex, as well as the mediating effect of heart function, through use of cardiac magnetic resonance (CMR) and mediation Mendelian randomization analysis. Methods: Mendelian randomization was employed to investigate the causal effect of hypertension on 68 cortical thickness (TH) or surface area (SA) traits of the cerebral cortex. Mediation analyses were conducted to identify potential CMR traits as mediators. Hypertension and heart function assessed by CMR were derived from genome-wide association (GWAS) summary data. The brain cortical imaging phenotypes were obtained from established biobank resources. Sensitivity analyses included Cochran's Q test, Mendelian randomization-Egger intercept test, and leave-one-out analyses. Results: Hypertension was causally associated with decreased middle temporal gyrus TH [odds ratio (OR) =0.96; P=0.006], increased middle temporal gyrus SA (OR =1.04, P=0.025), increased paracentral TH (OR =1.04, P=0.008), decreased banks of the superior temporal sulcus TH (OR =0.96, P=0.008), decreased isthmus cingulate TH (OR =0.96, P=0.012), and decreased posterior cingulate TH (OR =0.97, P=0.028). Certain CMR indices mediated the impact of hypertension on brain structure. Right ventricular end diastolic volume accounted for 20.25% of the total effect of hypertension on posterior cingulate TH (P=0.028), and right ventricular peak ejection rate accounted for 38.92% of the total effect of hypertension on middle temporal gyrus TH (P=0.036). No heterogeneity or pleiotropy was detected. Conclusions: A causal relationship between hypertension and brain cortical structure was confirmed. Heart function is involved in the mechanism of hypertension-induced changes in cerebral cortex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.