ArticleQuantitative imaging in medicine and surgery2025
Clinical and imaging characteristics of toxoplasmic encephalitis in patients with HIV/AIDS with different immune statuses.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Toxoplasmic encephalitis (TE) is one of the most common opportunistic central nervous system infections in patients with acquired immunodeficiency syndrome (AIDS) and a major cause of death. Magnetic resonance imaging (MRI) serves as a key adjunct in the clinical diagnosis of TE. This study aimed to identify the MRI characteristics of TE in patients with human immunodeficiency virus (HIV)/AIDS across different immune statuses. Methods: A retrospective analysis was conducted on the clinical and imaging data of hospitalized patients with AIDS and concurrent TE treated at two centers between January 2019 and December 2023. Patients were divided into three groups based on CD4 Results: A total of 41 patients were included, 82.9% had multiple lesions on MRI, and 203 lesions larger than 2 mm were identified. The lesions predominantly presented with nodular and ring-enhancing patterns, mainly distributed at the gray-white matter junction and the thalamus-basal ganglia region. In the comparison of MRI features between the three groups, patients with >100 CD4 Conclusions: In patients with HIV/AIDS with secondary TE, MRI findings varied in terms of lesion size and enhancement patterns according to the immune status of the patient. These imaging characteristics provide valuable guidance for the clinical diagnosis and treatment of TE.
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