Short-term prognosis of patients in different stages of severe tricuspid regurgitation after transcatheter tricuspid-valve replacement.

Background: The tricuspid regurgitation (TR) syndrome, based on the extent of cardiac and extracardiac involvement, is a newly proposed staging method to evaluate the progression of TR. This study aimed to explore cardiac structural characteristics and the short-term prognosis after transcatheter tricuspid valve replacement (TTVR) in patients at different stages. Methods: A post-hoc analysis of patients enrolled in the first-in-man and confirmatory study and an investigator-initiated trial of the LuX-Valve Plus system was conducted. Patients with TR who underwent successful TTVR by the LuX-Valve Plus systems were staged according to systemic involvement. The baseline and one-month follow-up results among different stages were compared. Results: A total of 149 patients were included, of whom 23 were in stage 2, 49 were in stage 3, and 77 were in stage 4. Compared with patients in stages 2 and 3, patients in stage 4 had more severe TR (mean vena contracta width: 14.94±4.51 Conclusions: The staging of TR syndrome may help to quantify disease severity. Although all patients can gain short-term benefits from TTVR, an early intervention may help to reduce the incidence of complications.