Evidence map›Paper›PMID 40785833›Full record

ReviewClinical, cosmetic and investigational dermatology2025

A Review: Causes, Consequences, and Management Strategies of Facial Overfilling.

Cheng-Xiang Peng, Wang Xv, Yin-Jie Ao

Abstract readReview
In one paragraph

Review in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Facial Overfilled Syndrome: A Narrative Clinical Review.Clinical, cosmetic and investigational dermatology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cheng-Xiang PengDepartment of General Surgery Ward 3, Plastic Surgery and Medical Cosmetic Center, Yichun People's Hospital, Yichun, People's Republic of China.
Wang XvPlastic Surgery and Medical Cosmetic Center, Yichun People's Hospital, Nanchang, People's Republic of China.
Yin-Jie AoPlastic Surgery and Medical Cosmetic Center, the Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, Overfilled Syndrome and the associated "Bread Bun" phenomenon have garnered significant attention in the field of aesthetic medicine, particularly among younger populations. This article systematically reviews the causes, consequences, and management strategies of facial overfilling, aiming to provide a scientific basis for the prevention and correction of this phenomenon. The causes of overfilling involve technical, patient, and physician-related factors: technical factors include improper injection dosage, depth, and point design; patient factors primarily stem from the excessive pursuit of "perfect" facial features and unrealistic expectations; while physician factors are related to insufficient experience, lack of technical proficiency, and misinterpretation of aesthetic standards. The consequences of overfilling include aesthetic imbalance, health risks, and psychological issues. To effectively prevent and manage overfilling, this article proposes detailed preventive strategies, including preoperative assessment and design, patient education, intraoperative layered injection techniques, and regular postoperative follow-ups. For cases where overfilling has already occurred, non-surgical correction and surgical correction are the primary treatment methods. Additionally, psychological support and the application of portable ultrasound technology play important roles in the correction process. Future research directions include the development of quantitative assessment tools, optimization of prevention and management strategies, and the development of new filler materials and technologies. Through scientific preventive strategies, precise treatment plans, and ongoing research and innovation, the occurrence of overfilling can be effectively reduced, advancing facial filler procedures toward greater safety and naturalness.

Indexed as

bread bunhyaluronic acidhyaluronidaseoverfilled syndromeportable ultrasound

Identifiers

PMID40785833
PMCPMC12333868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.