Evidence map›Paper›PMID 40785824›Full record

ArticleCirculation reports2025

Feature-Tracking Method Can Estimate Right Ventricular Contractile Properties in Rats With Pulmonary Hypertension.

Haruka Sato, Yui Takahashi, Taiki Hasegawa, Yuka Someya, Masami Nishiyama, Ayana Matsumoto, Natsuki Morita, Chiyohiko Shindoh, Hideki Ota, Ryuta Kawashima and 1 more

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In one paragraph

Article in Circulation reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Three-Color SUVCirculation reports · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haruka SatoDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Yui TakahashiDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Taiki HasegawaDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Yuka SomeyaDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Masami NishiyamaDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Ayana MatsumotoDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Natsuki MoritaDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Chiyohiko ShindohDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.
Hideki OtaDepartment of Diagnostic Radiology, Tohoku University Hospital Sendai Japan.
Ryuta KawashimaInstitute of Development, Aging and Cancer, Tohoku University Sendai Japan.
Masahito MiuraDepartment of Clinical Physiology, Health Science, Tohoku University Graduate School of Medicine Sendai Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Right ventricular (RV) function is a prognostic factor in patients with pulmonary arterial hypertension (PAH). Cardiovascular magnetic resonance (CMR) imaging has been used to assess RV function. However, it is not determined whether RV longitudinal strain (LS) with a feature-tracking method can accurately assess RV contractility. In this study, feature-tracking-based RVLS and RV ejection fraction (RVEF) were compared with contractile properties of RV muscle obtained from rat hearts with PAH. Methods and Results: Monocrotaline (MCT-rats, n=19) or solvent (Ctr-rats, n=4) was injected subcutaneously into rats. Four weeks after the injection, retrospective electrocardiogram-gated cine magnetic resonance (8 phases/beat) was imaged using a 7-T magnetic resonance imaging (MRI) scanner and RV pressure was measured. Trabeculae were dissected from the RV and electrically stimulated. Force was measured and maximum dF/dt was calculated as a parameter of contractile properties. Compared with Ctr-rats, MCT-rats showed higher systolic RV pressure. RVLS in all MCT-rats was lower than that in Ctr-rats, while RVEF was preserved (>40%) in 8 out of 16 MCT-rats. MCT-rats showed lower developed force and maximum dF/dt than Ctr-rats. Maximum dF/dt was linearly correlated with RVLS. In contrast, whether RVEF was preserved, maximum dF/dt was decreased in MCT-rats. Conclusions: The present study suggests that RVLS with a feature-tracking method can assess RV contractile properties more accurately than RVEF in rats with PAH. It is useful to estimate the RV function based on feature tracking.

Indexed as

Cardiovascular magnetic resonance (CMR)Contractile propertyFeature trackingPulmonary arterial hypertensionStrain

Identifiers

PMID40785824
PMCPMC12331350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.