ArticleCirculation reports2025
Controlled Nutritional Status Scores and Bleeding Events in Lower Extremity Arterial Disease - 3-Year Clinical Outcome Study.
Article in Circulation reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Usefulness of the Geriatric Nutritional Risk Index for Assessing Outcomes in Lower Extremity Artery Disease Following Endovascular Therapy.Circulation reports · 2026Article
- Clinical Outcomes of Anticoagulation Therapy With Direct Oral Anticoagulants or Warfarin in Patients With Atrial Fibrillation and Renal Impairment After Bioprosthetic Valve Replacement.Circulation reports · 2026Article
- Implementation of an Enteral Nutrition Protocol in the Cardiac Care Unit - A Retrospective Study of Critically Ill Cardiovascular Patients.Circulation reports · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Malnutrition has been associated with poor prognosis in patients with lower extremity arterial disease (LEAD). Malnutrition can influence adverse bleeding events in patients with coronary artery disease. However, the association between bleeding events and malnutrition in patients with LEAD remains unclear. Therefore, this study evaluated the association between nutritional screening with controlled nutritional status (CONUT) score and bleeding events in patients with LEAD. Methods and Results: This single-center retrospective observational study included 297 patients with LEAD who underwent endovascular therapy between January 2016 and December 2021. The high CONUT group was compared with the low CONUT group. The primary outcome was freedom from bleeding events, which was defined as Bleeding Academic Research Consortium type 3 or type 5. The high CONUT group had significantly higher cumulative bleeding events than the low CONUT group (log-rank P value <0.0001). Univariate analysis revealed that patients with a high CONUT score (hazard ratio [HR] 4.48; 95% confidence Interval [CI] 1.92-10.4; P=0.0005), chronic limb-threatening ischemia (HR 5.30; 95% CI 2.07-13.5; P=0.0005), non-ambulatory (HR 3.12; 95% CI 1.11-8.77; P= 0.03), and chronic kidney disease on hemodialysis (HR 4.01; 95% CI 1.72-9.33; P=0.001) had significantly more bleeding events than those with low CONUT scores. Conclusions: A high CONUT score at admission is closely associated with bleeding events in patients with LEAD.
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