Evidence map›Paper›PMID 40785734›Full record

ArticleDrug and alcohol dependence reports2025

A humanized monoclonal antibody attenuates carfentanil self-administration in nonhuman primates.

Lindsey K Galbo-Thomma, Carly Baehr, Elaine A Gay, Scott Runyon, Marco Pravetoni, Charles P France

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. An antifentanyl monoclonal antibody reverses fentanyl-induced apnea in pigs.The Journal of pharmacology and experimental therapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lindsey K Galbo-ThommaDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, United States.
Carly BaehrDepartment of Pharmacology, University of Minnesota Medical School, 321 Church St SE, Minneapolis, MN 55455, United States.
Elaine A GayCenter for Drug Discovery, RTI International, 3040 E Cornwallis Rd, Research Triangle Park, NC 27713, United States.
Scott RunyonCenter for Drug Discovery, RTI International, 3040 E Cornwallis Rd, Research Triangle Park, NC 27713, United States.
Marco PravetoniDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, United States.
Charles P FranceDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, United States.

Funding

Development of a monoclonal antibody to reverse overdose from fentanyl and its analogs: from manufacturing to clinical trialsUH3DA057850 · NIDA · UNIVERSITY OF WASHINGTON · PI SANDRA D. COMER, Marco Pravetoni · 2025 to 2026
$7.0M
NIDA NIH HHS UH3 DA057850
6 · The paper itself

Abstract

Approximately 70 % of fatal drug overdoses in the United States are attributed to fentanyl and fentanyl analogs. Current medications for reversing overdose and treating opioid use disorder might not be as effective against fentanyl and fentanyl analogs compared with other opioids, possibly due to their lipophilicity and high potency at the

Indexed as

CarfentanilFentanylFentanyl analogMonoclonal antibodyNonhuman primateOpioid use disorder

Identifiers

PMID40785734
PMCPMC12332196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.