Evidence map›Paper›PMID 40785576›Full record

ArticleNMR in biomedicine2025

Comparison of Brain Oxygen Metabolic Parameters Between Constrained qBOLD and Whole-Brain Oximetric Methods at Baseline and in Response to a Physiologic Stimulus.

Kathryn M Jaroszynski, Hyunyeol Lee, Michael C Langham, Felix W Wehrli

Abstract readComparative Study
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kathryn M JaroszynskiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hyunyeol LeeSchool of Electronic and Electrical Engineering, Kyungpook National University, Daegu, Republic of Korea.ORCID https://orcid.org/0000-0002-3941-6578
Michael C LanghamDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Felix W WehrliDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Training in Structural, Physiologic and Functional MRIT32EB020087 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI JAMES C GEE, Chamith Sudesh Rajapakse · 2016 to 2026
$2.1M
Simultaneous PET/MR Imaging of Brain Glucose and Oxygen Metabolism to Assess Energy Deficits Related to Alzheimer's Disease and the Response to InterventionR01NS131235 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Keith St. Lawrence, Felix W Wehrli · 2024 to 2026
$1.4M
MRI-Based Regional Assessment of Cerebral Metabolism Via 3D Quantitative BOLDR21EB031364 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2022 to 2023
$447k
Ministry of Science and ICT, South Korea RS-2023-00304695NIBIB NIH HHS P41 EB029460NIBIB NIH HHS R21 EB031364NIBIB NIH HHS T32 EB020087NIH HHS P41 EB029460NIH HHS R21 EB031364NIH HHS T32 EB020087NINDS NIH HHS R01 NS131235
6 · The paper itself

Abstract

The measurement of cerebral oxygen metabolism is important to understand and treat many disorders. Constrained quantitative BOLD (qBOLD) MRI is a calibration-free method for 3D voxel-wise whole-brain mapping of brain oxygen metabolism. This study aimed to evaluate the agreement between constrained qBOLD and global oximetry methods both at baseline and in response to a caffeine stimulus. Healthy volunteers (N = 10, age 30 ± 8 years) were imaged with constrained qBOLD, MOTIVE (metabolism of oxygen via T

Indexed as

BrainMagnetic Resonance ImagingOximetryOxygenAdultCaffeineCerebrovascular CirculationFemaleHumansMaleYoung AdultCaffeineOxygen3D MRIblood flowbrain mappingbrain metabolismoxygenation

Identifiers

PMID40785576
PMCPMC12337088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.