SynthesisThe Prostate2025
Is There Any Association Between Periodontitis and Prostatic Alterations? A Systematic Review.
Synthesis in The Prostate, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association between Periodontal Status and Prognosis in Men with Prostatitis: A Cross-Sectional Clinical Study.European journal of dentistry · 2026Article
- Genetic Polymorphisms and Antioxidant Reactions in Prostate Cancer.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe prostate plays a crucial role in male reproduction but is susceptible to diseases such as prostate cancer. Periodontitis, as an inflammatory disease, has the potential to modulate systemic conditions. This systematic review aimed to evaluate the association between periodontitis and prostatic alterations.
methodsThe review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines and registered in the PROSPERO database (CRD42024614333). Observational studies comparing the presence of periodontitis in men with and without prostatic alterations were included. The search strategy was applied to databases such as PubMed, Scopus, Embase, Web of Science and Lilacs, as well as gray literature (OpenGrey and Google Scholar). The selection of studies and data extraction were carried out independently by two reviewers. Methodological quality was assessed using the tools of the Joanna Briggs Institute, and confounding factors were analyzed using multivariate models, where applicable.
resultsA total of 769 references were identified, and 14 studies were included. Most studies indicated a significant association between periodontitis and prostate cancer, with a higher risk in patients with periodontal disease. Associations with BPH and chronic prostatitis were also observed in fewer studies. However, methodological limitations, such as inadequate control of confounding factors (e.g. smoking, genetics and age), heterogeneity in diagnostic criteria and reliance on self-reported data, increased the risk of bias. Many studies did not adequately adjust for confounding factors, compromising the robustness of the evidence.
conclusionThus, the findings suggest a potential association between periodontitis and prostatic alterations, especially prostate cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.