ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2025
Fungi as models of centromere innovation: from DNA sequence to 3-dimensional arrangement.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- 40 years of CENP-A: the foundation of a new era of centromere biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Faithful chromosome segregation is facilitated by the centromeres, specialized genomic loci, which connect chromosomes to microtubules in every cell cycle by recruiting the kinetochore complex. However, a single conserved code does not govern the formation and maintenance of centromeres, as we begin to realize that enormous diversity exists in molecular mechanisms dictating centromere homeostasis across species. The fungal kingdom is a vast resource to study and appreciate the divergent nature of the conserved phenomenon of chromosome segregation. Studies in the fungal kingdom enable researchers to view the evolution of centromeres at the molecular level. While some organisms, such as Saccharomyces cerevisiae, rely on a strict genetically determined centromere establishment, most fungi adopt epigenetically driven mechanisms of centromere propagation. This epigenomic regulation ranges from modifications on the underlying DNA to histones forming the centric and pericentric regions. The centromere DNA sequence, arrangement of sequence elements, its transcription state, and the replication timing, as well as its spatial position in the nucleus, play a major role in determining centromere stability and its function. In this review, we aim to highlight the spectrum of centromere regulatory mechanisms observed in fungi and discuss the gaps in the research that can provide new perspectives on centromere biology.
Indexed as
Identifiers
40785015What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.