Evidence map›Paper›PMID 40785008›Full record

ArticleMikrochimica acta2025

ZrMOF-based bimetallic nanotags enable dual-channel electrochemical biosensing for parallel and ultrasensitive detection of S. typhimurium and E. coli O157:H7.

Xiaodong Cao, Chenlu Zhang, Yu Gao, Weina Yu, Chao Liu, Shudong He, Hanju Sun, Yongkang Ye

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in Immunological Methods for the Detection ofSensors (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaodong Cao *School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Chenlu Zhang *School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Yu GaoSchool of Food and Biological Engineering, Xuancheng Campus, Hefei University of Technology, Xuancheng, 242000, China.
Weina YuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Chao LiuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Shudong HeSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Hanju SunSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Yongkang YeSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China. yongkang.ye@hfut.edu.cn.

Funding

Entrusted Projects by Enterprises W2023JSKF1100Provincial College Students Innovation and Entrepreneurship Training Program S202510359418
6 · The paper itself

Abstract

Foodborne pathogens are a leading cause of food safety incidents. Here, we developed a highly sensitive dual-channel biosensor for the parallel electrochemical detection of Salmonella typhimurium (S. typhimurium) and Escherichia coli (E. coli) O157:H7 using bimetallic metal-organic framework (BMOF)-based signal nanotags. The BMOF-based nanotags were synthesized by functionalizing gold nanoparticle-doped CuZr-MOF with signal DNA sequences sDNA1 (forming sDNA1-AuNPs@CuZr-MOF nanotag) and PbZr-MOF with signal DNA sequence sDNA2 (forming sDNA2-AuNPs@PbZr-MOF nanotag). The biosensing platform was constructed using two glassy carbon electrodes (GCEs). Each GCE was sequentially modified, first with electrodeposited gold nanoparticles (depAu) and then with the corresponding capture DNA sequences (cDNA1 for channel 1 or cDNA2 for channel 2). Target detection was achieved on the sensing interface via sandwich hybridization: in channel 1, the invA gene of S. typhimurium (tDNA1) was recognized by both cDNA1 on the sDNA1-AuNPs@CuZr-MOF nanotag; similarly, in channel 2, the eaeA gene of E. coli O157:H7 (tDNA2) was recognized by both cDNA2 and sDNA2 on the sDNA2-AuNPs@PbZr-MOF nanotag. Leveraging the high stability and ease of surface modification of UiO-66 (Zr-MOF), along with the enhanced electrochemical oxidation signals from the introduced secondary metal ions (Cu

Indexed as

Biosensing TechniquesElectrochemical TechniquesEscherichia coli O157Metal NanoparticlesMetal-Organic FrameworksSalmonella typhimuriumDNA, BacterialElectrodesGoldLimit of DetectionZirconiumDNA, BacterialGoldMetal-Organic FrameworksZirconiumBimetallic metal–organic frameworkDNA-functionalized nanotagsDual-channel detectionElectrochemical pathogen sensorModified glassy carbon electrodeSignal enhancement

Identifiers

PMID40785008

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.