Evidence map›Paper›PMID 40785006›Full record

ArticleBrain imaging and behavior2025

White matter microstructural abnormalities related to emotional dysfunction and childhood trauma characterize adolescents with borderline personality disorder.

Xiaoping Yi, Xueying Wang, Liying Shen, Yan Fu, Qian Xiao, Jinfan Zhang, Jun Ding, Furong Jiang, Zhejia Zhang, Alessandro Grecucci and 1 more

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Article in Brain imaging and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xiaoping Yi *Department of Radiology, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, 410008, P.R. China.
Xueying Wang *Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.
Liying ShenMental Health Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, P.R. China.
Yan FuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.
Qian XiaoMental Health Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, P.R. China. xiaoqian851112@126.com.
Jinfan ZhangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.
Jun DingDepartment of Public Health, Shenzhen Mental Health Center, Shenzhen Kangning Hospital, Shenzhen, Guangdong, P. R. China.
Furong JiangMental Health Center of Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, P.R. China.
Zhejia ZhangDepartment of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, P.R. China.
Alessandro GrecucciDepartment of Psychology and Cognitive Sciences (DiPSCo), University of Trento, Rovereto, Italy, 38068, TN, Italy.
Bihong T ChenDepartment of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, 91010, USA.

Funding

the Youth Fund of National Natural Science Foundation of China 82201702
6 · The paper itself

Abstract

backgroundThe neurobiological mechanism underlying adolescent borderline personality disorder (BPD) remains unclear. This study aimed to assess white matter (WM) microstructural abnormalities associated with emotional dysfunction and childhood trauma in adolescents with BPD.

methodsThis study enrolled 53 adolescents aged 12-17 years with BPD and 39 healthy controls (HC). Radial diffusivity (RD) and axial diffusivity (AD) were generated using Tract-Based Spatial Statistics (TBSS) analysis of the diffusion tensor imaging (DTI) data. Correlation analysis was conducted to assess the relationship of the DTI parameters with non-suicidal self-injurious behavior (NSSI) and childhood trauma in adolescents with BPD.

resultsAdolescents with BPD had lower AD values in the splenium of the corpus callosum, left anterior corona radiata and left external capsule, but higher RD values in the genu of the corpus callosum, body of the corpus callosum, right anterior corona radiata, and right uncinate fasciculus as compared to the HC group (p < 0.05, 5000 permutations). Increased RD values in the body of corpus callosum and right uncinate fasciculus were positively correlated with the NSSI score (p < 0.05). Increased RD value in the right anterior corona radiata was positively correlated with childhood trauma (p < 0.05).

conclusionsThis study identified alterations within the cortical-limbic system in adolescents with BPD, which was correlated with NSSI and childhood trauma. WM diffusivity parameters may serve as potential neuroimaging biomarkers in adolescents with BPD.

Indexed as

Adverse Childhood ExperiencesAffective SymptomsBorderline Personality DisorderWhite MatterAdolescentBrainChildCorpus CallosumDiffusion Tensor ImagingEmotionsFemaleHumansMaleSelf-Injurious BehaviorAdolescentsBorderline personality disorderDiffusion tensor imaging (DTI)Emotional dysfunctionWhite matter

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PMID40785006

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