Evidence map›Paper›PMID 40784997›Full record

ArticleAnnals of surgical oncology2026

Recurrence After Esophagectomy for Esophageal Cancer: High-Volume Center Surveillance Imaging Outcomes.

Sheuli Chowdhury, Thitiporn Chobarporn, Molly A Conroy, Lye-Yeng Wong, Siting Chen, John G Hunter, Alia P Qureshi, Stephanie G Wood

Abstract read
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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Factors associated with anticipatory grief in family caregivers of patients with esophageal cancer: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sheuli Chowdhury *Division of General Surgery, Department of Surgery, University of Vermont Medical Center, Burlington, Vermont, USA.
Thitiporn Chobarporn *Department of Surgery, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Molly A ConroyDivision of Foregut and Bariatric Surgery, Department of Surgery, Oregon Health & Science University School of Medicine, Portland, Oregon, USA.
Lye-Yeng WongDivision of Foregut and Bariatric Surgery, Department of Surgery, Oregon Health & Science University School of Medicine, Portland, Oregon, USA.
Siting ChenSchool of Public Health, Oregon Health & Science University, Portland, Oregon, USA.
John G HunterDivision of Foregut and Bariatric Surgery, Department of Surgery, Oregon Health & Science University School of Medicine, Portland, Oregon, USA.
Alia P QureshiDivision of Foregut and Bariatric Surgery, Department of Surgery, Oregon Health & Science University School of Medicine, Portland, Oregon, USA.
Stephanie G WoodDivision of Foregut and Bariatric Surgery, Department of Surgery, Oregon Health & Science University School of Medicine, Portland, Oregon, USA. woodste@ohsu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite treatment advancements, esophageal cancer survival remains poor due to high recurrence rates. Early detection of recurrence may allow for timely treatment and improved outcomes. This study evaluated recurrence patterns and detection methods using different imaging surveillance strategies after esophagectomy.

methodsA retrospective study reviewed patients who underwent esophagectomy for cancer at a high-volume National Cancer Institute (NCI)-designated comprehensive cancer center from 2007 to 2019. Postoperative surveillance followed a protocol based on the CROSS trial incorporating routine computed tomography (CT) imaging and clinical exams. Statistical analyses included independent t tests for continuous variables and chi-square tests for categorical variables. Times to recurrence and survival were calculated using Kaplan-Meier and compared by the log-rank test. Multivariate analysis used binary logistic regression.

resultsAmong 368 patients, 302 (82.1 %) received neoadjuvant chemoradiation. Recurrence occurred for 140 (38 %) patients, with more than 80 % of the recurrences detected within 2 years after surgery. In a multivariate analysis, lymphovascular invasion and clinical stage 3 disease were associated with recurrence. Clinically driven imaging discovered 61 (43.6 %) of the 140 recurrence cases, whereas routine surveillance imaging identified 77 (55 %) of the cases. The median time to recurrence was 9.4 months. The patients whose recurrence was detected through routine surveillance had a longer survival than those whose recurrence was detected by clinically driven imaging (median survival, 29.3 vs 17.7 months, respectively; p < 0.05).

conclusionsThe incidence of early recurrence is high after trimodality therapy (CROSS regimen) for esophageal cancer. Routine imaging surveillance combined with clinical examination as a surveillance protocol is necessary for early detection and timely treatment.

Indexed as

Esophageal NeoplasmsEsophagectomyHospitals, High-VolumeNeoplasm Recurrence, LocalTomography, X-Ray ComputedAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoadjuvant TherapyPrognosisRetrospective StudiesSurvival Rate

Identifiers

PMID40784997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.