Evidence map›Paper›PMID 40784996›Full record

ArticleAnnals of surgical oncology2025

Hashimoto's Thyroiditis Shows Sex- and Age-Dependent Inverse Associations with Papillary Thyroid Carcinoma Progression: A Propensity Score-Matched Analysis of 6963 Surgical Cases.

Chi Ma, Jie Xu, Guibin Zheng, Lujia Liu, Xicheng Song, Haitao Zheng

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
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8citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Chi Ma *Department of Thyroid Surgery, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China.
Jie Xu *Department of Nutrition, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China.
Guibin ZhengDepartment of Thyroid Surgery, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China.
Lujia LiuDepartment of Thyroid Surgery, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China.
Xicheng SongDepartment of Otolaryngology and Head and Neck Surgery, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China. drxchsong@163.com.
Haitao ZhengDepartment of Thyroid Surgery, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, Shandong Province, China. zhenghaitao1972@sdu.edu.cn.ORCID http://orcid.org/0009-0008-6756-5723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe coexistence of papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) presents a clinically significant yet controversial association in endocrine pathology. This study aimed to systematically evaluate the potential inverse associations between HT and PTC progression through comprehensive clinicopathological analysis.

methodsWe conducted a retrospective cohort study of 6963 surgical PTC patients treated at our tertiary referral center between 2009 and 2023. Using propensity score matching to control for baseline confounders, we performed Chi-square tests and logistic regression analyses adjusted for key pathological parameters.

resultsOverall, 6963 patients were included in this study. Analysis revealed that male patients with PTC had a lower risk of concurrent HT (odds ratio [OR] 0.29, p < 0.001) and HT-positive patients were significantly younger than their HT-negative counterparts (p = 0.02). Propensity score-matched analysis demonstrated that HT served as a protective factor against lymph node metastasis (OR 0.802, p < 0.001), tumor capsular invasion (OR 0.86, p = 0.004), and BRAF V600E mutation (OR 0.579, p = 0.039). In subgroup analyses, the association between HT and PTC was exclusively observed in female patients, with its correlation with reduced lymph node metastasis primarily seen in the <55 years age group, while the inverse association with capsular invasion was more pronounced in the ≥55 years age group.

conclusionThese findings suggest potential sex- and age-dependent associations between HT and less aggressive PTC characteristics, with the strongest correlations observed for reduced metastatic tendency in younger women and decreased local invasion in older patients. The observed BRAF mutation modulation suggests potential immune-mediated tumor microenvironment alterations warranting further molecular investigation.

Indexed as

Hashimoto DiseaseThyroid Cancer, PapillaryThyroid NeoplasmsAdultAgedAge FactorsDisease ProgressionFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedPrognosisPropensity ScoreProto-Oncogene Proteins B-rafBRAF protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID40784996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.