Evidence map›Paper›PMID 40784973›Full record

ArticleScientific reports2025

High risk of hepatic complications in kidney transplantation with chronic hepatitis C virus infection.

Shih-Ting Huang, Ya-Wen Chuang, Chih-Wei Chiu, Kuo-Ting Sun, Shih-Sheng Chang, I-Kuan Wang, Brain K Lee, Shiang-Cheng Kung, Chi-Yuan Li, Tung-Min Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shih-Ting Huang *Division of Nephrology, Taichung Veterans General Hospital, Taiwan Boulevard Sect. 4, Taichung, 40705, Taiwan.
Ya-Wen Chuang *Division of Nephrology, Taichung Veterans General Hospital, Taiwan Boulevard Sect. 4, Taichung, 40705, Taiwan.
Chih-Wei ChiuDivision of Nephrology, Taichung Veterans General Hospital, Taiwan Boulevard Sect. 4, Taichung, 40705, Taiwan.
Kuo-Ting SunGraduate Institute of Biomedical Sciences, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Shih-Sheng ChangCollege of Medicine, China Medical University, Taichung, Taiwan.
I-Kuan WangGraduate Institute of Biomedical Sciences, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Brain K LeeDell Seton Medical Center, University of Texas, Austin, USA.
Shiang-Cheng KungDepartment of Medicine, Division of Nephrology, UCSF Medical Center, San Francisco, CA, USA.
Chi-Yuan LiGraduate Institute of Biomedical Sciences, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Tung-Min YuDivision of Nephrology, Taichung Veterans General Hospital, Taiwan Boulevard Sect. 4, Taichung, 40705, Taiwan. yu5523@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data on liver issues including liver cirrhosis, hepatocellular carcinoma, and hepatic failure in renal transplant patients with HCV infection are scarce. In the present study, we conducted a large-scale population-based analysis to investigate the long-term outcomes of renal recipients with HCV infection. Propensity score matching with a ratio of 1:1 was applied. A total of 6,473renal recipients with HCV infection in case group were enrolled after PSM. Our findings showed that subjects with HCV infection in kidney transplant had significantly higher risk of hepatoma, cirrhosis, hepatic failure, and overall hepatic disease than those without HCV infection. (hepatoma: HR: 8.957; 95% CI: 5.324-15.069; cirrhosis: HR: 5.378; 95% CI: 4.363-6.631; hepatic failure: HR: 3.258; 95% CI: 2.527-4.200; overall hepatic disease: HR: 4.128; 95% CI: 3.428-4.971). In the present study, our findings show that renal recipients with HCV infection is significantly associated with a remarkably high risk of hepatic complications post-kidney transplantation.

Indexed as

Hepatitis C, ChronicKidney TransplantationLiver CirrhosisPostoperative ComplicationsAdultCarcinoma, HepatocellularFemaleHepacivirusHumansLiver NeoplasmsMaleMiddle AgedRisk FactorsDialysisEnd-stage renal diseaseHepatic diseaseHepatitis C virusKidney transplantation

Identifiers

PMID40784973
PMCPMC12336315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.