Evidence map›Paper›PMID 40784952›Full record

ReviewEcho research and practice2025

Clinical research and trials in echocardiography: rationale, requirements and future opportunities.

Casey L Johnson, Ross Upton, Samuel Krasner, Sadie Bennett, Ashley Ackerman, Xing Liu, Daniel X Augustine, Maria F Paton, Paul Leeson

Abstract readReview
In one paragraph

Review in Echo research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Casey L JohnsonOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 1, Oxford, OX3 9DU, UK.
Ross UptonOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 1, Oxford, OX3 9DU, UK.
Samuel KrasnerOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 1, Oxford, OX3 9DU, UK.
Sadie BennettOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 1, Oxford, OX3 9DU, UK.
Ashley AckermanUltromics Ltd., Oxford, UK.
Xing LiuOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 1, Oxford, OX3 9DU, UK.
Daniel X AugustineRoyal United Hospitals Bath NHS Foundation Trust, Bath, UK.
Maria F PatonLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Paul LeesonOxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Level 1, Oxford, OX3 9DU, UK. paul.leeson@cardiov.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Echocardiography has established itself as a vital component in the diagnosis and management of cardiovascular disease, evolving alongside advancements in imaging technology and clinical research methodologies. Since its inception in the 1950s, echocardiographic research has progressed from small-scale, observational studies to large cohort investigations and randomised controlled trials. This evolution has paralleled advancements in disease diagnosis and facilitated the use of echocardiography as an important player in other disciplines such as cardio-oncology and interventional cardiology. Echocardiography research has made great progress, with new developments rapidly shaping the field. This continued innovation underscores the singular focus of improving patient care. As digital and technological advancements accelerate, the potential for research in echocardiography to enhance diagnostic precision, guide personalised treatment, and improve outcomes on a global scale is greater than ever. Collaborative efforts and sustained investment in research will be key to realising these goals and advancing the care of patients with cardiovascular disease. This review explores the historical and ongoing contributions of echocardiography research to better understanding cardiac disease, emphasising the pivotal roles of early feasibility studies and large-scale trials in refining techniques and establishing clinical utility. Key infrastructure requirements for advancing echocardiography research are identified, including workforce development, academic and healthcare collaborations, clinical trial support, and access to big data and computational expertise. Emerging technologies, such as advanced imaging techniques, handheld devices, and AI-driven analytics, are highlighted as transformative tools poised to address current limitations in clinical practice.

Indexed as

Artificial intelligenceCardiovascular diseaseClinical researchClinical trialsEchocardiography

Identifiers

PMID40784952
PMCPMC12337415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.