ArticleScientific reports2025
Time series analysis of ex-vivo ischemia-reperfused heart using Q-space imaging.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In the evaluation of myocardial infarction, cardiac MRI remains problematic in terms of sensitivity and quantitativeness. Thus, we sought to delineate pathological microstructural alterations across temporal phases subsequent to myocardial ischemia-reperfusion (IR) injury utilizing q-space imaging (QSI), an advanced diffusion imaging methodology proficient in assessing the non-Gaussian diffusion patterns of molecules. Rats were subjected to IR injury, and infarct was evaluated at 2, 7, and 30 days via histopathological staining and MRI using a 9.4-Tesla system. QSI was performed with gadolinium-enhanced T1-weighted imaging (T1WI) for comparative assessment. Correlation coefficients among images were computed at each level of the left ventricular short-axis cross-section to juxtapose the infarct dimensions and morphology. Axial diffusivity of the kurtosis maps at 2, 7, and 30 days revealed substantial correlations with the hyperintense areas noted on T1WI (R
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