Evidence map›Paper›PMID 40784878›Full record

ArticleRenal failure2025

Mitochondrial DNA methylation is involved in contrast-induced renal tubular epithelial cell injury.

Meiling Lv, Manyu Zhang, Sha Chen, Sheng Lu, Dingwei Yang

Abstract read
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meiling LvClinical College of Orthopedics, Tianjin Medical University, Tianjin, China.
Manyu ZhangDepartment of Nephrology, Tianjin Hospital of Tianjin University, Tianjin, China.
Sha ChenDepartment of Nephrology, Tianjin Hospital of Tianjin University, Tianjin, China.
Sheng LuDepartment of Nephrology, Tianjin Hospital of Tianjin University, Tianjin, China.
Dingwei YangClinical College of Orthopedics, Tianjin Medical University, Tianjin, China.ORCID 0000-0003-1675-3667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial DNA (mtDNA) methylation may be associated with mitochondrial damage; this study investigates their relationship in contrast-induced renal tubular epithelial cell (RTEC) injury. We stimulated HK-2 cells with iohexol to establish an

Indexed as

Contrast MediaDNA MethylationDNA, MitochondrialEpithelial CellsIohexolKidney TubulesMitochondriaApoptosisCell LineCell SurvivalDecitabineElectron Transport Complex IVHumansMembrane Potential, MitochondrialReactive Oxygen SpeciesContrast MediaDecitabineDNA, MitochondrialElectron Transport Complex IVIohexolReactive Oxygen SpeciesapoptosisCI-AKImitochondrial damageMitochondrial DNA methylationROS

Identifiers

PMID40784878
PMCPMC12337735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.