Evidence map›Paper›PMID 40784675›Full record

ArticleThe Journal of physiology2025

Diet-induced obesity in mice increases carotid body chemosensitivity via the leptin-TRPM7 pathway.

Arijit Roy, Mi-Kyung Shin, Dashdulam Davaanyam, Noah Williams, Sean M Lee, Wan-Yee Tang, Vsevolod Y Polotsky

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arijit RoyDepartment of Anesthesiology & Critical Care Medicine, The George Washington University, Washington, DC, USA.ORCID 0009-0000-4383-4521
Mi-Kyung ShinDepartment of Anesthesiology & Critical Care Medicine, The George Washington University, Washington, DC, USA.
Dashdulam DavaanyamDepartment of Anesthesiology & Critical Care Medicine, The George Washington University, Washington, DC, USA.ORCID 0009-0003-6983-1611
Noah WilliamsDepartment of Anesthesiology & Critical Care Medicine, The George Washington University, Washington, DC, USA.
Sean M LeeDepartment of Surgery, Office of Clinical Research, The George Washington University, Washington, DC, USA.ORCID 0000-0002-9897-3315
Wan-Yee TangDepartment of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Vsevolod Y PolotskyDepartment of Anesthesiology & Critical Care Medicine, The George Washington University, Washington, DC, USA.ORCID 0000-0002-2951-7535

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026
$7.1M
NHLBI NIH HHS R01 HL133100
6 · The paper itself

Abstract

Diet-induced obesity (DIO) is associated with increased circulating level of the hormone leptin. We have previously shown that leptin augments hypoxic ventilatory response in mice, and the response is abolished by carotid body (CB) denervation, and that leptin induces hypertension in DIO acting on transient receptor potential melastatin 7 (Trpm7) channels in CB. However CB chemosensory responses in DIO have not been sufficiently elucidated. The aim of this study was to examine the effects of DIO and leptin on carotid sinus nerve (CSN) activity and the role of Trpm7 at normoxic and hypoxic conditions. We measured afferent CSN activity using a novel ex vivo perfused CB preparation in four groups of mice on the C57BL/6J background: lean wild type, DIO wildtype, Trpm7

Indexed as

Carotid BodyLeptinObesityTRPM Cation ChannelsAnimalsDiet, High-FatHypoxiaMaleMiceMice, Inbred C57BLSignal TransductionLeptinTrpm7 protein, mouseTRPM Cation Channelscarotid bodyhypertensionleptinobesityTrpm7

Identifiers

PMID40784675
PMCPMC12811058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.