ArticleJournal of advanced research2026
Non-solvent cinnamic acid-based gel patch for transdermal drug delivery.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionDrugs entitled polymeric network special functions in bio-applications. However, the introduction of appropriate solvent for drugs generally incurred tedious inclusion methods, intensive chemical design and aging caused by solvent loss. Herein, a novel non-solvent gel system was proposed for water-insoluble drug loading and subsequent controlled transdermal drug release.
objectivesThe purpose of this work is related to prepare a non-solvent transdermal gel patch loaded with cinnamic acid (CA) for the treatment of myocardial ischemia (MI), wound healing, etc.
methodsThe non-solvent transdermal gel patch was easily synthesized by melting the mixture of CA, thioctic acid (TA) and zinc acetate dihydrate. Basic gel properties such as chemical architecture, mechanical strength, swelling property, rheology, adhesive property, surface hydrophilicity and antibacterial activity were studied. Biocompatibility was evaluated by in vitro NIH3T3 cell culture and in vivo subcutaneous implantation. Transdermal drug delivery was revealed by a HPLC method for in vitro transdermal assay. A SD rat dorsal full-thickness open wound model and a SD rat MI model were involved to verify the therapeutic effect of this gel patch.
resultsThe prepared gel patch contained both physical crosslinking and chemical crosslinking points. As viewed by mechanical and rheological tests, the gel exhibited ductility, viscoelasticity and self-healing property. The gel showed wide-scope adhesion towards various materials, in which the maximum tissue adhesion strength reached 0.12 MPa. The transdermal CA release rate was ranged from 20 to 40 µg/h. In prospect of histological analysis from MI treatment, this gel was also capable of repairing myocardial injury, promoting angiogenesis and inhibiting myocardial cell hypertrophy.
conclusionThis work opened an approach in the field of gel patch design for transdermal drug delivery, which was promising in large scale production and biomedical applications.
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