Evidence map›Paper›PMID 40784448›Full record

ArticleThe Journal of biological chemistry2025

Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1.

Aashish Shivkumar, Kyle R Berg, Kevin C Sibucao, Geoffray Leriche, Lara E Dozier, Carla A Espinoza, Gentry N Patrick, Zied Gaieb, Christian Seitz, Rommie E Amaro and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Neuronal Actin Remodeling and Its Role in Higher Nervous Activity.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aashish ShivkumarDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Kyle R BergDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Kevin C SibucaoDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Geoffray LericheDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Lara E DozierThe Section of Neurobiology in the Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Carla A EspinozaDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Gentry N PatrickThe Section of Neurobiology in the Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Zied GaiebDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Christian SeitzDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Rommie E AmaroDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA.
Hyun-Hee ParkDepartment of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, South Korea.
Hyang-Sook HoeDepartment of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu, South Korea.
Jacob WozniakDepartment of Pharmacology and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
David J GonzalezDepartment of Pharmacology and the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Saptarshi SinhaDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, USA.
Pradipta GhoshDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, University of California San Diego, La Jolla, California, USA.
Jerry YangDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, USA. Electronic address: jerryyang@ucsd.edu.

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026
$4.8M
Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal InflammationR01AI141630 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pradipta Ghosh · 2019 to 2026
$3.2M
Equipment Supplement to 'Development of promoters of dendritic spine formation'R01AG053577 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YANG, JERRY · 2016 to 2020
$1.9M
MODULATION OF CELL SIGNALING BY PSEUDOMONAS EXOENZYME SR01AI045569 · NIAID · WEST VIRGINIA UNIVERSITY · PI OLSON, JOAN C. · 2000 to 2003
$1.0M
NIAID NIH HHS R01 AI045569NIAID NIH HHS R01 AI141630NIA NIH HHS R01 AG053577NIBIB NIH HHS T32 EB009380NIGMS NIH HHS T32 GM007240
6 · The paper itself

Abstract

Identifying new drug targets to enhance memory and learning is essential for treating neurodegenerative diseases, such as Alzheimer's disease. We previously showed that benzothiazole amphiphiles can improve memory and learning by increasing dendritic spine and synaptic density in both WT mice and in a transgenic Alzheimer's model mice. The cellular target for this class of compounds, however, was unknown. Using a photoaffinity-labeling approach, we identify fascin-1 as the major protein target in neurons for these compounds. These compounds enhance spine density by directly modulating actin dynamics, increasing the capability of fascin-1 to bundle actin filaments. Molecular docking and structure-guided mutagenesis studies reveal a distinct binding site on fascin-1, differing in both location and function from previously reported fascin-1-targeting molecules, opening exciting new avenues for selectively tuning fascin-1 activity in the brain.

Indexed as

BenzothiazolesCarrier ProteinsDendritic SpinesMicrofilament ProteinsAlzheimer DiseaseAnimalsHumansMiceMice, TransgenicMolecular Docking SimulationReceptors, OdorantBenzothiazolesCarrier ProteinsMicrofilament ProteinsOlfr73 protein, mouseReceptors, OdorantactinAlzheimer’s diseasebenzothiazolesdendritic spinefascinmolecular dockingmutagenesisneuron

Identifiers

PMID40784448
PMCPMC12926044

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.