Evidence map›Paper›PMID 40784438›Full record

ArticlePharmacological research2025

Distinctive biochemical properties of the μ-opioid receptor-corticotropin- releasing factor CRF

William N Sanchez, Estefanía Moreno, Marc Ciruela-Jardí, Nil Casajuana-Martín, Anne Yauch, Ning-Sheng Cai, Cesar Quiroz, Ya Gin Chang, Vicent Casadó, Leonardo Pardo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William N SanchezIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Estefanía MorenoLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
Marc Ciruela-JardíLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain; Laboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra, Spain.
Nil Casajuana-MartínLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra, Spain.
Anne YauchDepartments of Pharmaceutical Sciences, and Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, at the Bouve College of Health Sciences and College of Science, Northeastern University, Boston, MA, USA.
Ning-Sheng CaiIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Cesar QuirozIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Ya Gin ChangIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Taiwan International Graduate Program, National Yang Ming Chiao Tung University, Interdisciplinary of Neurosciences, Taipei, Taiwan; Academia Sinica, Institute of Biomedical Sciences, Neuroscience, Taipei, Taiwan.
Vicent CasadóLaboratory of Molecular Neuropharmacology, Department of Biochemistry and Molecular Biomedicine, Faculty of Biology and Institute of Biomedicine, University of Barcelona, Barcelona, Spain.
Leonardo PardoLaboratory of Computational Medicine, Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra, Spain.
Leigh D PlantDepartments of Pharmaceutical Sciences, and Center for Drug Discovery, School of Pharmacy and Pharmaceutical Sciences, at the Bouve College of Health Sciences and College of Science, Northeastern University, Boston, MA, USA.
Sergi FerréIntegrative Neurobiology Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. Electronic address: sferre@intra.nida.nih.gov.

Funding

Neurotransmitter Receptor Heteromers in the Striatal Spine ModuleZIADA000493 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI FERRE, SERGI · 2009 to 2025
$35.6M
Intramural NIH HHS ZIA DA000493
6 · The paper itself

Abstract

Heteromerization of Gs with Gi protein-coupled receptors has been suggested to be necessary to sustain the canonical Gi-Gs antagonistic interaction at adenylyl cyclase (AC). These heteromers have a tetrameric quaternary structure, composed by two homodimers each one coupled to its corresponding G protein. We describe the heterotetramer formed by the Gi-coupled μ-opioid receptor (MOR) and the Gs-coupled corticotropin releasing factor CRF

Indexed as

Receptors, Corticotropin-Releasing HormoneReceptors, Opioid, muAdenylyl CyclasesAnalgesics, OpioidAnimalsCRF Receptor, Type 1HEK293 CellsHumansProtein MultimerizationAdenylyl CyclasesAnalgesics, OpioidCRF Receptor, Type 1Receptors, Corticotropin-Releasing HormoneReceptors, Opioid, muCalcium signalingCentral amygdalaCRF(1) receptorHeteromersPhospholipase Cμ-opioid receptor

Identifiers

PMID40784438
PMCPMC12368769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.