Evidence map›Paper›PMID 40784434›Full record

ArticleToxicology and applied pharmacology2025

Gestational exposure to micro and nanoplastics differentially impacts cardiac development and function in male and female rats throughout the lifespan.

Chelsea M Cary, Samantha Adams, Gina M Moreno, Talia N Seymore, Marianne Polunas, Michael J Goedken, Xiang Wang, Edward J Yurkow, Phoebe A Stapleton

Abstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chelsea M CaryDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA.
Samantha AdamsDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA.
Gina M MorenoDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA.
Talia N SeymoreDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA.
Marianne PolunasResearch Pathology Services, Rutgers University, 41 Gordon Rd, Piscataway, NJ 08854, USA.
Michael J GoedkenResearch Pathology Services, Rutgers University, 41 Gordon Rd, Piscataway, NJ 08854, USA.
Xiang WangMolecular Imaging Core, Rutgers University, 675 Hoes Lane, Piscataway, NJ 08854, USA.
Edward J YurkowMolecular Imaging Core, Rutgers University, 675 Hoes Lane, Piscataway, NJ 08854, USA.
Phoebe A StapletonDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Rd, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Rd, Piscataway, NJ 08854, USA. Electronic address: stapleton@eohsi.rutgers.edu.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI HELMUT ZARBL · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Microvascular mechanisms of growth restriction after environmental toxicant exposureR01ES031285 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI STAPLETON, PHOEBE · 2021 to 2025
$3.5M
Mitochondrial Mechanisms, Microvascular Function, and Gestational NanotoxicologyR00ES024783 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI STAPLETON, PHOEBE · 2017 to 2019
$747k
Uteroplacental Vasculature and Fetal Growth after Plastic Particle ExposureF31ES035256 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI CARY, CHELSEA · 2023 to 2025
$80k
NIEHS NIH HHS F31 ES035256NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R00 ES024783NIEHS NIH HHS R01 ES031285NIEHS NIH HHS T32 ES007148
6 · The paper itself

Abstract

Micro- and nanoplastics (MNPs) are a ubiquitous contaminant. Identification of MNPs in the human placenta suggests this toxicant poses a danger to developing offspring. Previously, we demonstrated that maternal pulmonary MNP exposure restricts fetal growth and disrupts fetoplacental cardiovascular function in rats. Herein, we investigated how repeated maternal inhalation of polyamide-12 MNP from gestational day 4-19 during pregnancy (10 mg/m

Indexed as

HeartMaternal ExposureMicroplasticsPrenatal Exposure Delayed EffectsAnimalsFemaleMaleParticle SizePregnancyRatsRats, Sprague-DawleyMicroplasticsCardiovascularDOHaDFetal growth restrictionMicroplasticsNanoplasticsParticulate matter

Identifiers

PMID40784434
PMCPMC12967220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.