Evidence map›Paper›PMID 40784065›Full record

Trial reportDrug and alcohol dependence2025

Longitudinal effects of interoceptive awareness training as an adjunct to medication treatment for opioid use disorder: A randomized clinical trial of Mindful Awareness in Body-oriented Therapy.

Cynthia J Price, Kenneth C Pike, Joseph O Merrill

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04082637 (Mindful Body Awareness Training as an Adjunct to Medication Treatment for Opioid Use Disorder), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04082637 nacompletednot on this map

Mindful Body Awareness Training as an Adjunct to Medication Treatment for Opioid Use Disorder

TypeinterventionalSponsorUniversity of WashingtonRan2019 to 2024Enrolled303ConditionsOpioid-use DisorderArmsMindful Awareness in Body-oriented Therapy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cynthia J PriceDepartment of Biobehavioral Nursing and Health Informatics, University of Washington, Box 357266, Seattle, WA 98195, United States. Electronic address: cynthiap@uw.edu.
Kenneth C PikeOffice of Nursing Research, University of Washington, University of Washington, Box 357266, Seattle, WA 98195, United States.
Joseph O MerrillDepartment of Medicine, University of Washington, University of Washington, Seattle, WA 98195, United States.

Funding

Mindful Body Awareness Training as an Adjunct to Medication Assisted Treatment for Opioid Use Disorder: An ancillary studyR01AT010742 · NCCIH · UNIVERSITY OF WASHINGTON · PI MERRILL, JOSEPH O, PRICE, CYNTHIA J · 2019 to 2022
$2.4M
Mindful Body Awareness Training as an Adjunct to Medication Assisted Treatment for Opioid Use DisorderR33AT009932 · NCCIH · UNIVERSITY OF WASHINGTON · PI PRICE, CYNTHIA J · 2019 to 2021
$2.1M
NCCIH NIH HHS R01 AT010742NCCIH NIH HHS R33 AT009932
6 · The paper itself

Abstract

BACKGROUND AND

objectiveMedication for opioid use disorder (MOUD) treatment outcomes can be limited by co-occurring mental and physical conditions, and new adjunctive interventions are needed to improve treatment. Mindful Awareness in Body-oriented Therapy (MABT) teaches interoceptive awareness skills to promote well-being. This study evaluated the longitudinal effects of MABT as an adjunct to MOUD treatment.

methodsPatients stable on MOUD recruited from six community clinics were randomly assigned to MABT+MOUD or MOUD. Five assessments delivered over one year (N = 303) examined abstinence from non-prescribed opioid and overall substance use (primary outcomes), and secondary outcomes of mental and physical health distress, interoceptive and mindfulness skills, and opioid craving. An intent-to-treat approach to examine change across time involved generalized estimating equations and linear mixed multilevel models.

resultsThis sample demonstrated high percent days abstinence from non-prescribed opioids and other substances, resulting in no statistical between-group differences over time. Significant overall longitudinal effects for MABT+MOUD vs. MOUD were evident on secondary outcomes of physical symptom frequency, and interoceptive awareness. In addition, significant baseline to 12 month between-group improvements were evident on PTSD symptoms, emotion regulation difficulties, and mindfulness skills.

conclusionsWhile stable on MOUD, this sample had high levels of chronic pain and mental health distress. The results highlight improved longitudinal health outcomes in response to MABT critical to support recovery on MOUD. The MABT completion rate and maintained use of MABT skills over 12 months demonstrates MABT implementation feasibility and positive intervention response as an adjunct to MOUD treatment. PREREGISTRATION CLINICALTRIALS.GOV: NCT04082637.

Indexed as

AwarenessInteroceptionMind-Body TherapiesMindfulnessOpioid-Related DisordersAdultCombined Modality TherapyFemaleHumansLongitudinal StudiesMaleMiddle AgedTreatment OutcomeBuprenorphineComplementary therapyInteroceptionMethadoneMind-bodyMindfulnessOpioid use disorder

Identifiers

PMID40784065
PMCPMC12365928

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.