ArticleJoint diseases and related surgery2025
Neuropathic pain in knee osteoarthritis: Prevalence, diagnosis, and clinical implications.
Article in Joint diseases and related surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- DN4-Positive Neuropathic Pain Features in End-Stage Knee Osteoarthritis Awaiting Arthroplasty: Prevalence and Relationship With Function and Quality-of-Life.International journal of rheumatic diseases · 2026Article
- Acupotomy Alleviates Pain and Attenuates Spinal Neuronal Hyperexcitability in Knee Osteoarthritis Rats: Implication of the CaMKII/GluA1 Axis.Journal of pain research · 2026Article
- Magnetoencephalographic Spectral Abnormalities and Explainable Machine Learning of Neuropathic-Like Pain in Knee Osteoarthritis.Journal of pain research · 2026Article
- Pain Phenotypes in Knee Osteoarthritis: Between Mechanistic Taxonomy and Clinical Complexity.Orthopaedic surgery · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
objectivesThis study aims to explore the prevalence of neuropathic pain (NP) in patients with knee osteoarthritis (KOA) and to assess its correlation with functional status. PATIENTS AND
methodsBetween December 2023 and May 2024, a total of 193 patients (48 males, 145 females; mean age: 58.7±12.8 years; range, 22 to 89 years) who were diagnosed with KOA and had persistent knee pain for more than three months were included. The painDETECT and Douleur Neuropathique en 4 Questions (DN4) questionnaires were utilized to evaluate NP. The Visual Analog Scale (VAS) was used to assess pain severity, while the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was utilized to assess functional status.
resultsThe painDETECT indicated NP in 27.5% of patients, while the DN4 scale showed 30.6%. Patients with NP exhibited significantly elevated VAS and WOMAC scores to patients without NP, indicating a greater severity of pain and functional impairment in this subgroup (p<0.05). The agreement between the painDETECT and DN4 was moderate (κ=0.472). There were significant correlations between the painDETECT and DN4 scores with the WOMAC total score (r=0.371 and r=0.242, respectively, p<0.001).
conclusionNeuropathic pain is common in KOA patients and is associated with higher pain intensity and poorer functional outcomes. The moderate agreement between the painDETECT and DN4 scores may lead to a certain degree of diagnostic variation. Combining more than one method may increase the diagnostic accuracy.
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