ArticleJoint diseases and related surgery2025
Potential preventive effects of angiotensin-(1-7) on bone matrix quality in diabetic rats through modulation of the organic matrix.
Article in Joint diseases and related surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThis experimental study aims to investigate the effects of angiotensin (1-7) (Ang-[1-7]) on the microstructural, biomechanical, and biophysicochemical properties of bone tissue in diabetic rats. MATERIALS AND
methodsForty-eight male Wistar rats, aged three months and weighing between 280 and 330 g, were used in this study. Four groups, each containing 12 rats, were established: Control, diabetes mellitus (DM), DM-Ang-(1-7), and Ang-(1-7). The samples underwent analysis through micro-computed tomography (CT), Raman spectroscopy, and three-point bending biomechanical test.
resultsDiabetes significantly impaired bone quality, with reduced cortical thickness, maximum load, and flexural strength (p<0.05). The Ang-(1-7) treatment improved flexural strength (p<0.05), but did not fully restore mechanical function. Micro-CT showed decreased bone volume and trabecular thickness in both diabetic groups (p<0.05), with no significant recovery by Ang-(1-7). Raman spectroscopy revealed lower mineral-to-matrix ratio and disrupted collagen quality in diabetic bone (p<0.05), while Ang-(1-7) partially restored collagen-related parameters.
conclusionThese findings highlight that Ang-(1-7) has minimal impact on bone minerals in DM rats. However, it may have a potential preventive effect on the triple-helix structural impairment within the bone organic matrix in this model.
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