Evidence map›Paper›PMID 40783756›Full record

ArticleBMC biotechnology2025

E7 peptide and magnesium oxide-functionalized coaxial fibre membranes enhance the recruitment of bone marrow mesenchymal stem cells and promote bone regeneration.

Shengyu Long, Wentong Wang, Yongcheng Chen, Zhihua Wang, Hao Duan, Ping Yuan, Yunrong Xu, Denghui Li, Wan Zhang, Weizhou Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shengyu Long *Orthopedics, Qujing First People's Hospital, Qujing, Yunnan, 655000, China.
Wentong Wang *Trauma Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Yongcheng ChenOrthopedics Department, the First Affiliated Hospital of KunmingMedical University, Kunming, Yunnan, 650032, China.
Zhihua WangTrauma Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Hao DuanTrauma Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Ping YuanTrauma Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Yunrong XuOrthopedics, Qujing First People's Hospital, Qujing, Yunnan, 655000, China.
Denghui LiTrauma Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Wan ZhangTrauma Center, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
Weizhou WangOrthopedics Department, the First Affiliated Hospital of KunmingMedical University, Kunming, Yunnan, 650032, China. wangweizhou@kmmu.edu.cn.
Fei HeOrthopedics, Qujing First People's Hospital, Qujing, Yunnan, 655000, China. drhefei@126.com.

Funding

Cloud-Ridge Industry Technology Leader Grant from the Yunnan Development and Reform Commission Grant number:LXL20170046Joint Special Project of Kunming Medical University by the Yunnan Provincial Department of Science and Technology Grant number:202101AY070001-013National Natural Science Foundation of China Grant number:82160417Yunnan Provincial Education Department Scientific Research Fund Grant number:2024Y249
6 · The paper itself

Abstract

backgroundThe repair of bone defects remains a significant clinical challenge. Although magnesium (Mg)-based biomimetic scaffolds are widely utilized for bone defect repair, the release of Mg²⁺ ions often leads to an alkaline microenvironment, thereby adversely affecting bone regeneration. Regenerative medicine strategies that leverage the recruitment of endogenous bone marrow mesenchymal stem cells (BMSCs) offer a novel approach to treating bone defects.

methodsIn this study, we employed poly(L-lactic acid) (PLLA) and polyethylene glycol (PEG) as shell materials and nanomagnesium oxide (nMgO) combined with gelatin (G) as core materials to fabricate coaxial fibre membranes with a "core‒shell" structure via coaxial electrospinning technology. Additionally, we grafted the BMSC-affinitive peptide E7 (EPLQLKM) onto the fibres to achieve specific recruitment of endogenous BMSCs.

resultsMorphological and structural analyses confirmed the successful formation of the "core‒shell" structure of the fibre membranes. Grafting E7 peptides enhanced the hydrophilicity and mechanical properties of the fibre membranes and maintained pH stability in vitro. In vitro experiments demonstrated that the functionalized fibre membranes significantly promoted BMSC proliferation, migration, and osteogenic differentiation. When implanted into a rat cranial defect model, we observed the formation of new bone tissue and the repair of the bone defect.

conclusionsE7 peptide-functionalized coaxial fibre membranes effectively facilitated bone defect repair by promoting the recruitment and osteogenic differentiation of BMSCs, demonstrating substantial potential for tissue engineering applications.

Indexed as

Bone RegenerationMagnesium OxideMesenchymal Stem CellsPeptidesAnimalsBone Marrow CellsCell DifferentiationCell ProliferationCells, CulturedGelatinMaleMembranes, ArtificialOsteogenesisPolyestersPolyethylene GlycolsRatsGelatinMagnesium OxideMembranes, ArtificialPeptidesPolyestersPolyethylene Glycolspoly(lactide)Bone defect repairBone marrow mesenchymal stem cellsCoaxial fibre membranesE7 affinity peptideNanomagnesium oxide

Identifiers

PMID40783756
PMCPMC12335062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.