ArticleBMC surgery2025
Post-endoscopic retrograde cholangiopancreatography cholangitis after endoscopic treatment of post-transplant biliary strictures: a retrospective study.
Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Common Language for Post-Transplant Anastomotic Biliary Strictures: Standardized Endoscopic Outcome Definitions and a Failure-Mode Roadmap.Medicina (Kaunas, Lithuania) · 2026Review
- Sedation-related complications during ERCP in liver transplant recipients: a retrospective cohort study.BMC gastroenterology · 2026Article
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8 authors.
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Abstract
BACKGROUND AND
aimBiliary strictures after liver transplantation are associated with significant morbidity and mortality. Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred approach. Post-ERCP cholangitis is a complication of this procedure. We aimed to evaluate the incidence of post-ERCP cholangitis in patients with post-transplant biliary strictures, their impact on survival, and identify potential risk factors.
methodsThis retrospective study evaluated liver transplant recipients with biliary strictures treated with balloon dilatation at defined intervals. Primary clinical endpoints were the incidence of post-ERCP cholangitis, overall survival, and identification of potential risk factors.
resultsTwo hundred patients with a median follow-up period of 6 years (IQR 2-10 years) were included. Anastomotic and non-anastomotic strictures were diagnosed in 132 and 68 patients, respectively. Overall, 930 ERCP procedures were performed, and post-ERCP cholangitis was detected in 148 procedures (15.9%). Patients with post-ERCP cholangitis showed significantly worse overall survival rates (median, 9 vs. 15 years; log-rank test, p < 0.001), were significantly more frequently diagnosed with non-anastomotic strictures (44.6% vs. 25%; p = 0.004), and had significantly higher treatment failure rates (n = 24/92; 26.1% vs. n = 13/108; 12%; p = 0.02) compared to those without cholangitis. Independent risk factors for cholangitis included the presence of non-anastomotic strictures (OR 3.1), and first-time ERCP intervention with sphincterotomy (OR 6.31).
conclusionsPost-ERCP cholangitis is a relevant complication of endoscopic treatment and is associated with the presence of non-anastomotic strictures and higher treatment failure rates. Since the success rate of endoscopic intervention in these complex strictures is limited, an optimized peri-interventional management and tailored antibiotic therapy may become particularly important for the further treatment and prognosis of these patients.
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