ArticleBMC cardiovascular disorders2025
Evaluation of subclinical myocardial involvement in systemic lupus erythematosus using multiparametric cardiac magnetic resonance imaging.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Myocardial injury in systemic lupus erythematosus and lupus nephritis: a silent threat.Clinical kidney journal · 2026Review
- Comparison of cardiac MRI features of fibrosis and strain for early cardiac dysfunction assessment in patients with systemic lupus erythematosus and Sjögren's syndrome.Lupus science & medicine · 2026Article
- TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Myocarditis as the first sign of SLE: a case report and review of the literature.Rheumatology international · 2026Review
- Heart failure in autoimmune rheumatic diseases.Rheumatology international · 2026Review
- Metabolomic Signatures and Advanced Echocardiography Highlight Clinical Risk and Early Cardiac Changes in Systemic Lupus Erythematosus: Six-Year Follow-Up.Metabolites · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeThis study aimed to characterize subclinical myocardial involvement and assess the alterations in biventricular cardiac function in patients with systemic lupus erythematosus (SLE) using cardiac magnetic resonance (CMR) imaging.
methodThis study included 42 patients with SLE, categorized into two subgroups: those with subclinical myocardial involvement and a control group with no myocardial involvement. Additionally, 20 age- and sex-matched healthy controls (HCs) underwent CMR examinations. Cardiac parameters were compared among the three groups, and potential relationships between imaging findings and clinical measures were analyzed.
resultsIndividuals with subclinical myocardial involvement demonstrated increased LVEDVI, RVEDVI, native T1 values, ECV, and T2 values compared to the SLE control group and/or HCs. Conversely, reduced RVEF, LV-GCS, LV-GLS), LV- (D-LPSR/D-CPSR), RV-GLS, and D-LPSR were observed in this subgroup. C3 levels were negatively correlated with several CMR parameters(LV-GCS, LV-GLS, native T1,ECV, T2). PLT was negatively correlated with LV-GCS, while ESR showed a positive correlation with ECV.
conclusionAbnormal changes detected by the FT technique (e.g., myocardial strain, strain rate abnormalities) may precede the onset of a decline in EF, enabling detection of myocardial injury before ejection fraction decreases. LV GCS may serve as valuable indicators for identifying subclinical myocardial involvement in SLE, particularly in patients with contrast allergies or severe renal impairment.
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