ReviewDrug delivery and translational research2025
Mechanistic insights and clinical evidence of Helianthus annuus Linn. (Sunflower) seed oil for dermatological applications: A narrative review.
Review in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- β‑Caryophyllene-Loaded Sunflower Oil Nanoemulsion Incorporated into Chitosan Films for Wound Healing Applications.ACS omega · 2026Article
- Protective Effects of Exogenous Donkey Oil on Skin Healing Under Incisional Wound Damage.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Plant oils play an important role in natural product-based dermatological formulations owing to their multifunctional therapeutic properties. Among these, sunflower seed oil (SSO) has gained prominence due to its dual role as a barrier-restoring emollient and skin penetration enhancer. Rich in unsaturated fatty acids, particularly linoleic acid (LA) and oleic acid (OA), SSO supports skin health by restoring lipid bilayer organization, modulating ceramide synthesis, and activating peroxisome proliferator-activated receptor-alpha (PPAR-α). These mechanisms reinforce barrier integrity while facilitating transdermal delivery of active agents. However, oils high in OA and/or containing protein allergens may compromise barrier function and promote allergen penetration, necessitating careful evaluation of chemical composition and structural characteristics. Ex vivo studies using porcine skin models have demonstrated SSO ability to enhance the permeation of both hydrophilic and lipophilic compounds. Clinically, SSO has shown efficacy in reducing transepidermal water loss (TEWL), improving hydration, and accelerating wound healing in conditions such as xerosis and atopic dermatitis. Its favourable safety profile, biocompatibility, and successful incorporation into various dermatological and cosmeceutical formulations underscore its versatility. This review critically examines the molecular interactions between SSO and the skin barrier, with specific focus on its roles in barrier restoration, inflammation modulation and transdermal enhancement. Mechanistic insights from its fatty acid composition are integrated with ex vivo findings, supported by clinical evidence, to evaluate its therapeutic potential and utility as a multifunctional, plant-based excipient in modern topical drug delivery systems for human skin health.
Indexed as
Identifiers
40783675What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.